Self-harming behavior (SB) is one of the diagnostic criteria for borderline personality disorder (BPD). However, it is not exhibited by all individuals with BPD. Furthermore, studies examining the neural correlates of SB in BPD are lacking. Given research showing that BPD patients have difficulty habituating to affective stimuli, this study investigated whether anomalous amygdala activation is specific to BPD patients with SB. The authors used fMRI to compare amygdala activation in BPD patients with SB (n = 15) to BPD patients without SB (n = 18) and healthy controls (n = 32) during a task involving pleasant, neutral, and unpleasant pictures, presented twice. BPD patients with SB demonstrated greater amygdala activity during the second presentation of unpleasant pictures. Results highlight neurobiological differences in BPD patients with and without SB and suggest that anomalous amygdala habituation to unpleasant stimuli may be related to SB.

中文翻译：

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边缘性人格障碍和自残行为史的未服药个体对不愉快刺激的异常杏仁核习惯。

自残行为（SB）是边缘型人格障碍（BPD）的诊断标准之一。但是，并非所有患有 BPD 的人都表现出这种情况。此外，缺乏检查 BPD 中 SB 的神经相关性的研究。鉴于研究表明 BPD 患者难以适应情感刺激，本研究调查了异常杏仁核激活是否特定于患有 SB 的 BPD 患者。作者使用 fMRI 比较了 SB 的 BPD 患者（n = 15）与没有 SB 的 BPD 患者（n = 18）和健康对照组（n = 32）在涉及愉快、中性和不愉快图片的任务中的杏仁核激活，呈现两次. 患有 SB 的 BPD 患者在第二次呈现令人不快的图片时表现出更大的杏仁核活动。