Several image-based computational models have been used to perform mechanical analysis for atherosclerotic plaque progression and vulnerability investigations. However, differences of computational predictions from those models have not been quantified at multi-patient level. In vivo intravascular ultrasound (IVUS) coronary plaque data were acquired from seven patients. Seven 2D/3D models with/without circumferential shrink, cyclic bending and fluid–structure interactions (FSI) were constructed for the seven patients to perform model comparisons and quantify impact of 2D simplification, circumferential shrink, FSI and cyclic bending plaque wall stress/strain (PWS/PWSn) and flow shear stress (FSS) calculations. PWS/PWSn and FSS averages from seven patients (388 slices for 2D and 3D thin-layer models) were used for comparison. Compared to 2D models with shrink process, 2D models without shrink process overestimated PWS by 17.26%. PWS change at location with greatest curvature change from 3D FSI models with/without cyclic bending varied from 15.07% to 49.52% for the seven patients (average = 30.13%). Mean Max-FSS, Min-FSS and Ave-FSS from the flow-only models under maximum pressure condition were 4.02%, 11.29% and 5.45% higher than those from full FSI models with cycle bending, respectively. Mean PWS and PWSn differences between FSI and structure-only models were only 4.38% and 1.78%. Model differences had noticeable patient variations. FSI and flow-only model differences were greater for minimum FSS predictions, notable since low FSS is known to be related to plaque progression. Structure-only models could provide PWS/PWSn calculations as good approximations to FSI models for simplicity and time savings in calculation.

几种基于图像的计算模型已被用于对动脉粥样硬化斑块进展和脆弱性调查进行机械分析。然而，这些模型的计算预测差异尚未在多患者水平上进行量化。从七名患者获得体内血管内超声（IVUS）冠状动脉斑块数据。为七名患者构建了具有/不具有圆周收缩、循环弯曲和流固耦合 (FSI) 的 7 个 2D/3D 模型，以进行模型比较并量化 2D 简化、圆周收缩、FSI 和循环弯曲斑块壁应力/应变的影响(PWS/PWSn) 和流动剪切应力 (FSS) 计算。来自 7 名患者的 PWS/PWSn 和 FSS 平均值（2D 和 3D 薄层模型的 388 个切片）用于比较。与有收缩过程的 2D 模型相比，没有收缩过程的 2D 模型高估了 PWS 17.26%。对于 7 名患者，PWS 在具有/不具有循环弯曲的 3D FSI 模型中曲率变化最大的位置变化从 15.07% 到 49.52%（平均值 = 30.13%）。最大压力条件下纯流动模型的平均 Max-FSS、Min-FSS 和 Ave-FSS 分别比具有循环弯曲的全 FSI 模型高 4.02%、11.29% 和 5.45%。FSI 和仅结构模型之间的平均 PWS 和 PWSn 差异仅为 4.38% 和 1.78%。模型差异具有明显的患者差异。对于最小 FSS 预测，FSI 和仅流动模型差异更大，值得注意的是，因为已知低 FSS 与斑块进展有关。