BACKGROUND The aim of the study was to identify the value of extensive resection and reconstruction with flaps in the treatment of locoregionally advanced lateral skull-base cancer. PATIENTS AND METHODS The retrospective case review of patients with lateral skull-base cancer treated surgically with curative intent between 2011 and 2019 at a tertiary otorhinolaryngology referral centre was made. RESULTS Twelve patients with locoregionally advanced cancer were analysed. Lateral temporal bone resection was performed in nine (75.0%), partial parotidectomy in six (50.0%), total parotidectomy in one (8.3%), ipsilateral selective neck dissection in eight (66.7%) and ipsilateral modified radical neck dissection in one patient (8.3%). The defect was reconstructed with anterolateral thigh free flap, radial forearm free flap or pectoralis major myocutaneous flap in two patients (17.0%) each. Mean overall survival was 3.1 years (SD = 2.5) and cancer-free survival rate 100%. At the data collection cut-off, 83% of analysed patients and 100% of patients with flap reconstruction were alive. CONCLUSIONS Favourable local control in lateral skull-base cancer, which mainly involves temporal bone is achieved with an extensive locoregional resection followed by free or regional flap reconstruction. Universal cancer registry should be considered in centres treating this rare disease to alleviate analysis and multicentric research.

中文翻译：

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皮瓣在重建局部晚期外侧颅底癌缺损中的重要性：三级耳鼻喉科转诊中心的经验。

背景 本研究的目的是确定广泛切除和皮瓣重建在治疗局部晚期外侧颅底癌中的价值。患者和方法 对 2011 年至 2019 年在三级耳鼻喉科转诊中心接受手术治疗的侧颅底癌患者进行了回顾性病例回顾。结果 分析了 12 名局部晚期癌症患者。9 例 (75.0%) 进行了外侧颞骨切除术，6 例 (50.0%) 进行了腮腺部分切除术，1 例 (8.3%) 进行了腮腺全切除术，8 例 (66.7%) 进行了同侧选择性颈清扫术，1 例进行了同侧改良根治性颈清扫术(8.3%)。用大腿前外侧游离皮瓣重建缺损，桡侧前臂游离皮瓣或胸大肌肌皮瓣各 2 例 (17.0%)。平均总生存期为 3.1 年 (SD = 2.5)，无癌生存率为 100%。在数据收集截止时，83% 的分析患者和 100% 的皮瓣重建患者还活着。结论 外侧颅底癌（主要涉及颞骨）的良好局部控制是通过广泛的局部区域切除，然后进行游离或区域皮瓣重建实现的。治疗这种罕见疾病的中心应考虑进行通用癌症登记，以减轻分析和多中心研究的负担。83% 的分析患者和 100% 的皮瓣重建患者还活着。结论 外侧颅底癌（主要涉及颞骨）的良好局部控制是通过广泛的局部区域切除，然后进行游离或区域皮瓣重建实现的。治疗这种罕见疾病的中心应考虑进行通用癌症登记，以减轻分析和多中心研究的负担。83% 的分析患者和 100% 的皮瓣重建患者还活着。结论 外侧颅底癌（主要涉及颞骨）的良好局部控制是通过广泛的局部区域切除，然后进行游离或区域皮瓣重建实现的。治疗这种罕见疾病的中心应考虑进行通用癌症登记，以减轻分析和多中心研究的负担。