This systematic review evaluates single-case research design studies investigating applied behavior analytic (ABA) interventions for people with Down syndrome (DS). One hundred twenty-five studies examining the efficacy of ABA interventions on increasing skills and/or decreasing challenging behaviors met inclusion criteria. The What Works Clearinghouse standards and Risk of Bias in N-of-1 Trials scale were used to analyze methodological characteristics, and Tau-U effect sizes were calculated. Results suggest the use of ABA-based interventions are promising for behavior change in people with DS. Thirty-six high-quality studies were identified and demonstrated a medium overall effect. A range of outcomes was targeted, primarily involving communication and challenging behavior. These outcomes will guide future research on ABA interventions and DS.

中文翻译：

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对唐氏综合症患者应用行为分析干预的单一案例研究的元分析。

本系统评价评估了单案例研究设计研究，这些研究调查了唐氏综合症 (DS) 患者的应用行为分析 (ABA) 干预措施。125 项研究 ABA 干预对提高技能和/或减少挑战性行为的功效符合纳入标准。使用 What Works Clearinghouse 标准和 N-of-1 试验中的偏差风险量表来分析方法学特征，并计算 Tau-U 效应量。结果表明，使用基于 ABA 的干预措施有望改变 DS 患者的行为。确定了 36 项高质量的研究，并证明了总体效果中等。一系列结果是有针对性的，主要涉及沟通和具有挑战性的行为。这些结果将指导未来对 ABA 干预和 DS 的研究。