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P2GT: Fine-Grained Genomic Data Access Control With Privacy-Preserving Testing in Cloud Computing
IEEE/ACM Transactions on Computational Biology and Bioinformatics ( IF 4.5 ) Pub Date : 2021-03-03 , DOI: 10.1109/tcbb.2021.3063388
Qinlong Huang 1 , Wei Yue 1 , Yixian Yang 1 , Lixuan Chen 1
Affiliation  

With the rapid development of bioinformatics and the availability of genetic sequencing technologies, genomic data has been used to facilitate personalized medicine. Cloud computing, features as low cost, rich storage and rapid processing can precisely respond to the challenges brought by the emergence of massive genomic data. Considering the security of cloud platform and the privacy of genomic data, we first introduce P2GT which utilizes key-policy attribute-based encryption to realize genomic data access control with unbounded attributes, and employs equality test algorithm to achieve personalized medicine test by matching digitized single nucleotide polymorphisms (SNPs) directly on the users’ ciphertext without encrypting multiple times. We then propose an enhanced scheme P2GT+, which adopts identity-based encryption with equality test supporting flexible joint authorization to realize privacy-preserving paternity test, genetic compatibility test and disease susceptibility test over the encrypted SNPs with P2GT. We prove the security of proposed schemes and conduct extensive experiments with the 1,000 Genomes dataset. The results show that P2GT and P2GT+ are practical and scalable enough to meet the privacy-preserving and authorized genetic testing requirements in cloud computing.

中文翻译:

P2GT:云计算中具有隐私保护测试的细粒度基因组数据访问控制

随着生物信息学的快速发展和基因测序技术的普及,基因组数据已被用于促进个性化医疗。云计算具有成本低、存储丰富、处理速度快等特点,可以精准应对海量基因组数据涌现带来的挑战。考虑到云平台的安全性和基因组数据的隐私性,我们首先介绍了P2GT,它利用基于key-policy的属性加密来实现无界属性的基因组数据访问控制,并采用等式检验算法通过匹配数字化单证实现个性化医学检验。核苷酸多态性(SNP)直接在用户的密文上,无需多次加密。然后我们提出了一个增强的方案 P2GT+,采用基于身份的加密与平等测试支持灵活的联合授权,以P2GT对加密的SNP实现隐私保护亲子鉴定、遗传相容性测试和疾病易感性测试。我们证明了所提出方案的安全性,并使用 1,000 个基因组数据集进行了广泛的实验。结果表明,P2GT和P2GT+具有足够的实用性和可扩展性,足以满足云计算中的隐私保护和授权基因检测需求。
更新日期:2021-03-03
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