Objectives The Severe Acute Respiratory Distress Corona Virus 2 (SARS-CoV-2) pandemic poses special challenges for the society and especially the medical staff. Even if a rather mild course is assumed among pregnant women the measures to prevent transmission of the infection are of outstanding importance. Methods To screen asymptomatic pregnant women during admission to our university maternal hospital we focused on anti-SARS-CoV-2-specific IgG and IgA antibody responses. Hundred and fifty one women admitted to the hospital for childbirth or caesarean delivery were included. In case of suspicious anti-SARS-CoV-2-antibody levels an RT-PCR was performed to confirm an ongoing infection with SARS-CoV-2. Results A total of 89% showed negative results for anti-SARS-CoV-2-IgA antibodies, whereas 3% were borderline and 7% positive (both labeled as suspicious). In only one patient with suspicious serology we detected SARS-CoV-2-RNA in the following RT-PCR. 2% presented anti-SARS-CoV-2-IgG antibodies, all being positive for anti-SARS-CoV-2-IgA. The observed positive rate of our study collective of 10.6% seemed much higher than the expected one (1.3%) based on the reports of the Robert Koch Institute and the specifications given by the test’s manufacturer. The expected positive predictive value (PPV) was 4.3–6.7 times higher than the observed one. Conclusions To our knowledge this is the first report of anti-SARS-CoV-2-antibody levels in the peripartum period of asymptomatic women. As the positive anti-SARS-CoV-2 serology poorly correlated with the confirmatory RT-PCR and the fact that mainly the detection of the virus by PCR correlates with the patient’s infectiousness we suggest to rather perform a SARS-CoV-2-PCR-based admission screening in perinatal centers to prevent the spread of the disease.

中文翻译：

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区域性 SARS-CoV-2 爆发期间无症状孕妇的外周抗 SARS-CoV-2-IgA/IgG

目标 严重急性呼吸窘迫冠状病毒 2 (SARS-CoV-2) 大流行给社会，尤其是医务人员带来了特殊挑战。即使在孕妇中采取相当温和的过程，预防感染传播的措施也非常重要。方法 为了在我们大学产科医院住院期间筛查无症状孕妇，我们重点关注抗 SARS-CoV-2 特异性 IgG 和 IgA 抗体反应。包括因分娩或剖腹产而入院的 151 名妇女。如果出现可疑的抗 SARS-CoV-2 抗体水平，则进行 RT-PCR 以确认持续感染 SARS-CoV-2。结果 抗 SARS-CoV-2-IgA 抗体共有 89% 显示阴性结果，而 3% 处于临界状态，7% 为阳性（均标记为可疑）。在随后的 RT-PCR 中，我们仅在一名血清学可疑的患者中检测到了 SARS-CoV-2-RNA。2% 的人呈递抗 SARS-CoV-2-IgG 抗体，均呈抗 SARS-CoV-2-IgA 阳性。根据罗伯特·科赫研究所 (Robert Koch Institute) 的报告和测试制造商提供的规格，我们研究集体的观察到的阳性率为 10.6%，似乎远高于预期的阳性率 (1.3%)。预期阳性预测值 (PPV) 比观察值高 4.3-6.7 倍。结论 据我们所知，这是无症状妇女围产期抗 SARS-CoV-2 抗体水平的首次报告。