BACKGROUND To date, many compounds extracting from natural products have anti-tumor activity, such as citronellol, ellagitannin-containing pomegranate extract, etc. Evidence from clinical context shows that multidrug resistance is an obstacle that impedes the effectiveness of natural products, such as chemotherapeutic agents paclitaxel and vincristine. Overexpression of ATP-Binding Cassette (ABC) transporters is the leading cause of MDR. Therefore, it is crucial to investigate whether these natural products are substrates of MDR-associated ABC transporters, which may benefit the development of their clinical usage. OBJECTIVE This review summarizes the latest insight on natural products possessing substrate profile and analyzed some possible regularity to provide direction for future drug discovery. CONCLUSION The anti-tumor effects of natural products are constantly being explored, but the drug resistance issues cannot be ignored, which limits their prospects as anti-tumor drugs to a certain extent. At the same time, some natural products are taken as a daily diet, and their possible role in increasing the drug resistance of the substrate should arouse the attention of clinical cancer patients.

中文翻译：

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天然产物作为ABC转运蛋白的底物：综述。

背景技术迄今为止，从天然产物中提取的许多化合物都具有抗肿瘤活性，例如香茅酚，含鞣花单宁的石榴提取物等。临床证据表明，多药耐药性是阻碍天然产物（例如化学疗法）有效性的障碍。代理紫杉醇和长春新碱。ATP结合盒（ABC）转运蛋白的过表达是MDR的主要原因。因此，至关重要的是研究这些天然产物是否为与MDR相关的ABC转运蛋白的底物，这可能有益于其临床用途的发展。目的这篇综述总结了对具有底物特征的天然产物的最新见解，并分析了一些可能的规律性，以为将来的药物开发提供指导。结论天然产物的抗肿瘤作用一直在探索中，但耐药性问题不容忽视，这在一定程度上限制了其作为抗肿瘤药物的前景。同时，一些天然产品被当作日常饮食，它们在增加底物耐药性方面的可能作用应引起临床癌症患者的注意。