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Ultrasound-triggered immunotherapy for cancer treatment: An update.
Current Protein & Peptide Science ( IF 2.8 ) Pub Date : 2021-02-12 , DOI: 10.2174/1389203722666210212125526
Debasmita Mukhopadhyay 1 , Amal Ahmed 1 , Catherine Sano 2 , Nahid Awad 1 , Nour Al Sawaftah 1 , Ghaleb A Husseini 1
Affiliation  

Over the past few decades, immunotherapy has emerged as a promising therapeutic approach to treat some types of cancer. Moreover, antibody-based cancer therapies can trigger apoptosis and cell growth inhibition to induce immune cell destruction of target cells through antibody-dependent cellular cytotoxicity (ADCC). Nevertheless, immunotherapeutic efficiency is often restricted to either deficient delivery or low accumulation of therapeutic molecules at the tumor site. Therefore, exposing immunoliposomes to ultrasound can effectively improve drug accessibility by enhancing cell membrane permeability and drug release. This review summarizes existing traditional cancer treatments and their limitations, emphasizing the recent advancements in ultrasound-triggered immunotherapy.

中文翻译:

超声触发的免疫疗法用于癌症治疗:更新。

在过去的几十年中,免疫疗法已成为治疗某些类型癌症的一种有前途的治疗方法。而且,基于抗体的癌症疗法可以触发细胞凋亡和细胞生长抑制,从而通过抗体依赖性细胞毒性作用(ADCC)诱导靶细胞的免疫细胞破坏。然而,免疫治疗效率通常限于肿瘤分子处的递送不足或治疗分子的低积累。因此,将免疫脂质体暴露于超声可以通过增强细胞膜通透性和药物释放来有效改善药物可及性。这篇综述总结了现有的传统癌症治疗方法及其局限性,强调了超声触发免疫疗法的最新进展。
更新日期:2021-02-12
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