The Hierarchical Taxonomy of Psychopathology (HiTOP): A Quantitative Nosology Based on Consensus of Evidence,Annual Review of Clinical Psychology

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The Hierarchical Taxonomy of Psychopathology (HiTOP): A Quantitative Nosology Based on Consensus of Evidence
Annual Review of Clinical Psychology ( IF 18.4 ) Pub Date : 2021-05-07 , DOI: 10.1146/annurev-clinpsy-081219-093304
Roman Kotov ₁ , Robert F Krueger ₂ , David Watson ₃ , David C Cicero ₄ , Christopher C Conway ₅ , Colin G DeYoung ₂ , Nicholas R Eaton ₁ , Miriam K Forbes ₆ , Michael N Hallquist ₇ , Robert D Latzman ₈ , Stephanie N Mullins-Sweatt ₉ , Camilo J Ruggero ₄ , Leonard J Simms ₁₀ , Irwin D Waldman ₁₁ , Monika A Waszczuk ₁₂ , Aidan G C Wright ₁₃

Affiliation

Departments of Psychiatry and Psychology, Stony Brook University, Stony Brook, New York 11794, USA; email:
Department of Psychology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Department of Psychology, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Department of Psychology, University of North Texas, Denton, Texas 76203, USA.
Department of Psychology, Fordham University, Bronx, New York 10458, USA.
Centre for Emotional Health, Department of Psychology, Macquarie University, Macquarie Park, New South Wales 2109, Australia.
Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Department of Psychology, Georgia State University, Atlanta, Georgia 30303, USA.
Department of Psychology, Oklahoma State University, Stillwater, Oklahoma 74078, USA.
Department of Psychology, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Department of Psychology, Emory University, Atlanta, Georgia 30322, USA.
Department of Psychology, Rosalind Franklin University, North Chicago, Illinois 60064, USA.
Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Traditional diagnostic systems went beyond empirical evidence on the structure of mental health. Consequently, these diagnoses do not depict psychopathology accurately, and their validity in research and utility in clinicalpractice are therefore limited. The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium proposed a model based on structural evidence. It addresses problems of diagnostic heterogeneity, comorbidity, and unreliability. We review the HiTOP model, supporting evidence, and conceptualization of psychopathology in this hierarchical dimensional framework. The system is not yet comprehensive, and we describe the processes for improving and expanding it. We summarize data on the ability of HiTOP to predict and explain etiology (genetic, environmental, and neurobiological), risk factors, outcomes, and treatment response. We describe progress in the development of HiTOP-based measures and in clinical implementation of the system. Finally, we review outstanding challenges and the research agenda. HiTOP is of practical utility already, and its ongoing development will produce a transformative map of psychopathology.

中文翻译：

精神病理学的分层分类法 (HiTOP)：基于证据共识的定量分类法

传统的诊断系统超越了关于心理健康结构的经验证据。因此，这些诊断不能准确地描述精神病理学，因此它们在研究中的有效性和临床实践中的效用是有限的。精神病理学分层分类法 (HiTOP) 联盟提出了一个基于结构证据的模型。它解决了诊断异质性、合并症和不可靠性问题。我们在这个分层维度框架中回顾了 HiTOP 模型、支持证据和精神病理学的概念化。该系统尚不全面，我们描述了改进和扩展它的过程。我们总结了有关 HiTOP 预测和解释病因（遗传、环境和神经生物学）、危险因素、结果和治疗反应能力的数据。我们描述了基于 HiTOP 的措施开发和系统临床实施的进展。最后，我们回顾了突出的挑战和研究议程。HiTOP 已经具有实用价值，它的持续发展将产生一个变革性的精神病理学地图。

更新日期：2021-05-08

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