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The Hierarchical Taxonomy of Psychopathology (HiTOP): A Quantitative Nosology Based on Consensus of Evidence.
Annual Review of Clinical Psychology ( IF 18.4 ) Pub Date : 2021-02-12 , DOI: 10.1146/annurev-clinpsy-081219-093304
Roman Kotov 1 , Robert F Krueger 2 , David Watson 3 , David C Cicero 4 , Christopher C Conway 5 , Colin G DeYoung 2 , Nicholas R Eaton 1 , Miriam K Forbes 6 , Michael N Hallquist 7 , Robert D Latzman 8 , Stephanie N Mullins-Sweatt 9 , Camilo J Ruggero 4 , Leonard J Simms 10 , Irwin D Waldman 11 , Monika A Waszczuk 12 , Aidan G C Wright 13
Affiliation  

Traditional diagnostic systems went beyond empirical evidence on the structure of mental health. Consequently, these diagnoses do not depict psychopathology accurately, and their validity in research and utility in clinical practice are therefore limited. The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium proposed a model based on structural evidence. It addresses problems of diagnostic heterogeneity, comorbidity, and unreliability. We review the HiTOP model, supporting evidence, and conceptualization of psychopathology in this hierarchical dimensional framework. The system is not yet comprehensive, and we describe the processes for improving and expanding it. We summarize data on the ability of HiTOP to predict and explain etiology (genetic, environmental, and neurobiological), risk factors, outcomes, and treatment response. We describe progress in the development of HiTOP-based measures and in clinical implementation of the system. Finally, we review outstanding challenges and the research agenda. HiTOP is of practical utility already, and its ongoing development will produce a transformative map of psychopathology. Expected final online publication date for the Annual Review of Clinical Psychology, Volume 17 is May 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译:

精神病理学分级分类法(HiTOP):基于证据共识的定量分类学。

传统的诊断系统超越了关于心理健康结构的经验证据。因此,这些诊断不能准确地描述精神病理学,因此它们在研究中的有效性和在临床实践中的实用性受到限制。精神病理学分类法(HiTOP)联盟提出了一种基于结构证据的模型。它解决了诊断异质性,合并症和不可靠性的问题。我们回顾了HiTOP模型,支持证据以及此分层维度框架中的精神病理学概念。该系统尚不完善,我们描述了改进和扩展它的过程。我们总结了有关HiTOP预测和解释病因(遗传,环境和神经生物学),危险因素,结局和治疗反应的能力的数据。我们描述了基于HiTOP的措施的开发以及该系统的临床实施方面的进展。最后,我们回顾了尚待解决的挑战和研究议程。HiTOP已经具有实用性,其持续发展将产生精神病理学的变革地图。《临床心理学年度评论》(第17卷)的最终最终在线发布日期为2021年5月。有关修订的估算,请参见http://www.annualreviews.org/page/journal/pubdates。
更新日期:2021-02-12
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