During the approximately 5 days of Drosophila neurogenesis (late embryogenesis to the beginning of pupation), a limited number of neural stem cells produce approximately 200,000 neurons comprising hundreds of cell types. To build a functional nervous system, neuronal types need to be produced in the proper places, appropriate numbers, and correct times. We discuss how neural stem cells (neuroblasts) obtain so-called area codes for their positions in the nervous system (spatial patterning) and how they keep time to sequentially produce neurons with unique fates (temporal patterning). We focus on specific examples that demonstrate how a relatively simple patterning system (Notch) can be used reiteratively to generate different neuronal types. We also speculate on how different modes of temporal patterning that operate over short versus long time periods might be linked. We end by discussing how specification programs are integrated and lead to the terminal features of different neuronal types. Expected final online publication date for the Annual Review of Neuroscience, Volume 44 is July 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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果蝇发育过程中的集成模式程序产生神经元的多样性，并控制它们的成熟特性。

在果蝇神经发生（胚胎发育后期至化beginning开始）的大约5天内，有限数量的神经干细胞会产生大约200,000个神经元，其中包括数百种细胞类型。为了建立功能性神经系统，需要在适当的位置，适当的数量和正确的时间产生神经元类型。我们讨论了神经干细胞（神经母细胞）如何获取它们在神经系统中的位置的所谓区域代码（空间模式），以及它们如何保持时间依次产生具有独特命运的神经元（时间模式）。我们关注于特定的示例，这些示例演示了如何相对重复地使用图案系统（Notch）来迭代地生成不同的神经元类型。我们还推测了在短时间段与长时间段内运行的不同模式的时间模式可能如何关联。我们以讨论规范程序如何集成并最终导致不同神经元类型的终端特征为结尾。《神经科学年度评论》（第44卷）的最终最终在线发布日期为2021年7月。有关修订的估算，请参见http://www.annualreviews.org/page/journal/pubdates。