OBJECTIVE The main aim was to report the prevalence and severity of serious bacterial infections (SBI) in children with sickle cell disease at King Abdulaziz Hospital (KAH), Al Ahsa, Saudi Arabia, to aid in determining whether outpatient management of such cases is appropriate. METHODS We conducted a retrospective chart review of febrile children less than 14 years of age admitted with sickle cell disease 2005 through 2015. RESULTS During 320 admissions, 25 children had SBIs (8%) including pneumonia (n=11), osteomyelitis (n=8), bacteremia (n=3, all with Salmonella species) and UTI (n=3). All recovered uneventfully. CONCLUSION It appears that in the current era, less than 10% of febrile children with sickle cell disease in our center are diagnosed with an SBI. Over 11 years, there were no sequelae or deaths from SBI. Given these excellent outcomes, outpatient ceftriaxone should be considered for febrile well-appearing children with sickle cell disease if they have no apparent source and parents are judged to be reliable.

中文翻译：

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艾哈萨阿卜杜勒阿齐兹国王医院镰状细胞病儿童的严重细菌感染患病率。

目的 主要目的是报告沙特阿拉伯阿卜杜勒阿齐兹国王医院 (KAH) 镰状细胞病患儿的严重细菌感染 (SBI) 的患病率和严重程度，以帮助确定此类病例的门诊管理是否合适. 方法 我们对 2005 年至 2015 年因镰状细胞病入院的 14 岁以下发热儿童进行了回顾性图表审查。结果 在 320 名入院期间，25 名儿童患有 SBI（8%），包括肺炎（n=11）、骨髓炎（n= 8）、菌血症（n=3，所有沙门氏菌属）和尿路感染（n=3）。所有人都平安无事地康复了。结论 看来，在当前时代，我们中心只有不到 10% 的患有镰状细胞病的发热儿童被诊断为 SBI。11 年来，SBI 没有后遗症或死亡。