The trafficking of G protein–coupled receptors (GPCRs) to different membrane compartments has recently emerged as being a critical determinant of the signaling profiles of activation. GPCRs, which share many structural and functional similarities, also share many mechanisms that traffic them between compartments. This sharing raises the question of how the trafficking of individual GPCRs is selectively regulated. Here, we will discuss recent studies addressing the mechanisms that contribute to selectivity in endocytic and biosynthetic trafficking of GPCRs.

中文翻译：

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选择性 G 蛋白偶联受体定位和运输的机制

G 蛋白偶联受体 (GPCR) 向不同膜区室的运输最近已成为激活信号传导谱的关键决定因素。GPCR 具有许多结构和功能相似之处，也共享许多在区室之间传输它们的机制。这种共享提出了如何有选择地监管单个 GPCR 的贩运的问题。在这里，我们将讨论最近的研究，这些研究涉及 GPCR 内吞和生物合成运输的选择性机制。