Chronic inflammatory skin diseases (CISDs) negatively impact a large number of patients. Injection of triamcinolone acetonide (TA), an anti-inflammatory steroid drug, directly into the dermis of diseased skin using needle-syringe systems is a long-established procedure for treating recalcitrant lichenified lesions of CISDs, referred to as TA intralesional injection (TAILI). However, TAILI causes severe pain, causing patients to be stressed and reluctant to undergo treatment. Furthermore, the practitioner dependency on the amount and depth of the injected TA makes it difficult to predict the prognosis. Here, candle flame (“candlelit”)-shaped TA-loaded dissolving microneedles (Candlelit-DMN) are designed and fabricated out of biocompatible and biodegradable molecules. Candlelit-DMN distributes TA evenly across human skin tissue. Conjoined with the applicator, Candlelit-DMN is efficiently inserted into human skin in a standardized manner, enabling TA to be delivered within the target layer. In an in vivo skin inflammation mouse model, Candlelit-DMN inserted with the applicator effectively alleviates inflammation by suppressing inflammatory cell infiltration and cytokine gene expression, to the same extent as TAILI. This Candlelit-DMN with the applicator arouses the interest of dermatologists, who prefer it to the current TAILI procedure.

中文翻译：

---

用于慢性炎症性皮肤病的溶解烛光微针

慢性炎症性皮肤病 (CISD) 对大量患者产生负面影响。使用针头注射器系统将消炎类固醇药物曲安奈德 (TA) 直接注射到患病皮肤的真皮中是一种长期建立的治疗 CISD 顽固性苔藓化病变的方法，称为 TA 病灶内注射 (TAILI) . 然而，泰力会引起剧烈疼痛，导致患者压力大，不愿接受治疗。此外，从业者对注射 TA 的量和深度的依赖使得预测预后变得困难。在这里，蜡烛火焰（“烛光”）形 TA 负载溶解微针（Candlelit-DMN）是由生物相容性和可生物降解的分子设计和制造的。Candlelit-DMN 在人体皮肤组织中均匀分布 TA。Candlelit-DMN 与涂抹器相结合，以标准化的方式有效地插入人体皮肤，使 TA 能够在目标层内传递。在体内皮肤炎症小鼠模型中，插入涂药器的 Candlelit-DMN 通过抑制炎症细胞浸润和细胞因子基因表达来有效缓解炎症，其程度与 TAILI 相同。这种带有涂药器的 Candlelit-DMN 引起了皮肤科医生的兴趣，他们比目前的 TAILI 手术更喜欢它。与TAILI相同的程度。这种带有涂药器的 Candlelit-DMN 引起了皮肤科医生的兴趣，他们比目前的 TAILI 手术更喜欢它。与TAILI相同的程度。这种带有涂药器的 Candlelit-DMN 引起了皮肤科医生的兴趣，他们比目前的 TAILI 手术更喜欢它。