The utilization of the mRNA-based Pfizer-BioNTech and Moderna coronavirus disease 2019 (COVID-19) vaccines represents the culmination of many years of nonviral nucleic acid delivery, but more importantly, they signify a massive clinical scientific success. Scientists working in the area of nucleic acid delivery using lipid nanoparticles will undoubtedly be energized by the success of these vaccines and begin to collect much needed data in the realm of nonviral-based RNA and DNA delivery, specifically, the use of lipid nanoparticles, the immune response, safety, and efficacy. It is easily conceivable that in the future we can utilize these data to help streamline our approach for the delivery of DNA for gene therapy and regulatory RNAs for therapeutic and regenerative medicine (ie, wound repair) applications.

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COVID-19 疫苗告诉我们关于体内核酸递送的哪些信息？

基于m RNA 的 Pfizer-BioNTech 和 Moderna 冠状病毒病 2019 (COVID-19) 疫苗的使用代表了多年非病毒核酸递送的高潮，但更重要的是，它们标志着巨大的临床科学成功。使用脂质纳米粒子进行核酸递送领域的科学家们无疑会因这些疫苗的成功而受到鼓舞，并开始在基于非病毒的 RNA和 DNA递送领域收集急需的数据，特别是脂质纳米粒子的使用，免疫反应、安全性和有效性。不难想象，未来我们可以利用这些数据来帮助简化我们的DNA递送方法用于治疗和再生医学（即伤口修复）应用的基因治疗和调节 RNA 。