Abstract

A porous covalent triazine-based organic framework (CTF) containing amide hydrogen-bonding was synthesized using Pigment Orange 71 under Lewis acidic (ZnCl₂) conditions at 400 °C. The novel CTF material shows excellent chemical and thermal stability with 10% weight loss temperature up to 465 °C and owns a high surface area (960 m² g⁻¹) and a total pore volume of 0.48 cm³ g⁻¹. The pore size distribution calculated by the non-local density functional theory shows the single micropores center at about 1.5 nm. The CTF particles have an average size of 374 nm and display excellent size-selective adsorption performance, high anticancer drug Irinotecan (CPT-11) loading (27.9 wt%) capacity and outstanding pH-responsive release.

摘要

使用颜料橙 71 在路易斯酸性 (ZnCl ₂ ) 条件下，在 400 °C下合成了含有酰胺氢键的多孔共价三嗪基有机骨架 (CTF) 。新型 CTF 材料显示出优异的化学和热稳定性，在高达 465 °C 的温度下失重 10%，并具有高表面积 (960 m ² g ^-1 ) 和 0.48 cm ³ g ^-1的总孔体积. 非局域密度泛函理论计算的孔径分布显示单个微孔中心在1.5 nm左右。CTF 颗粒的平均粒径为 374 nm，显示出优异的尺寸选择性吸附性能、高抗癌药物伊立替康 (CPT-11) 负载量 (27.9 wt%) 和出色的 pH 响应性释放。