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Liposomes as vehicles for topical ophthalmic drug delivery and ocular surface protection
Expert Opinion on Drug Delivery ( IF 6.6 ) Pub Date : 2021-01-22 , DOI: 10.1080/17425247.2021.1872542
José Javier López-Cano 1, 2 , Miriam Ana González-Cela-Casamayor 1, 2 , Vanessa Andrés-Guerrero 1, 2 , Rocío Herrero-Vanrell 1, 2 , Irene Teresa Molina-Martínez 1, 2
Affiliation  

ABSTRACT

Introduction: The development of ophthalmic formulations able to deliver hydrophilic and hydrophobic drugs to the inner structures of the eye and restore the preocular tear film has been a leading topic of discussion over the last few years. In this sense, liposomes represent a suitable strategy to achieve these objectives in ocular drug delivery.

Areas covered: Knowledge of the different physiological and anatomical eye structures, and specially the ocular surface are critical to better understanding and comprehending the characteristics required for the development of topical ophthalmic liposomal formulations. In this review, several features of liposomes are discussed such as the main materials used for their fabrication, basic structure and preparation methods, from already established to novel techniques, allowing the control and design of special characteristics. Besides, physicochemical properties, purification processes and strategies to overcome delivery or encapsulation challenges are also presented.

Expert opinion: Regarding ocular drug delivery of liposomes, there are some features that can be redesigned. Specific biocompatible and biodegradable materials presenting therapeutic properties, such as lipidic compounds or polymers significantly change the way of tackling ophthalmic diseases. Besides, liposomes entail an effective, safe and versatile strategy for the treatment of diseases in the clinical practice.



中文翻译:

脂质体作为局部眼科药物递送和眼表保护的载体

摘要

简介:能够将亲水性和疏水性药物输送到眼睛内部结构并恢复眼前泪膜的眼科制剂的开发一直是过去几年的主要讨论话题。从这个意义上说,脂质体代表了在眼部药物递送中实现这些目标的合适策略。

涵盖的领域:不同生理和解剖眼结构的知识,特别是眼表,对于更好地理解和理解局部眼科脂质体制剂开发所需的特征至关重要。在这篇综述中,讨论了脂质体的几个特征,例如用于制造的主要材料、基本结构和制备方法,从已经建立的技术到新技术,允许控制和设计特殊特性。此外,还介绍了物理化学性质、纯化过程和克服递送或封装挑战的策略。

专家意见:关于脂质体的眼部给药,有一些特点可以重新设计。具有治疗特性的特定生物相容性和可生物降解材料,如脂质化合物或聚合物,显着改变了治疗眼科疾病的方式。此外,脂质体在临床实践中需要一种有效、安全和通用的治疗疾病的策略。

更新日期:2021-01-22
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