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Nomenclature for factors of the HLA system, update July, August and September 2020*
International Journal of Immunogenetics ( IF 2.2 ) Pub Date : 2020-10-30 , DOI: 10.1111/iji.12520
Steven G E Marsh 1
Affiliation  

The following sequences have been submitted to the Nomenclature Committee since the April, May and June 2020 nomenclature update (Marsh, 2020) and, following agreed policy, have been assigned official allele designations (Marsh et al., 2010). Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given, and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case, you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. In addition, the sequences for B*27:215N, DQA1*02:06 and DPA1*02:02:02:06Q were shown to be in error and identical to B*27:05:02:01, DQA1*02:01:01:01 and DPA1*02:02:02:01, respectively. The names B*27:215N, DQA1*02:06 and DPA1*02:02:02:06Q have now been abandoned. Additionally, the alleles C*12:274:02N, MICA*008:07 and E*01:21:02N were named in error and have now been renamed C*12:329N, MICA*008:01:10 and E*01:117N, respectively. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IPD-IMGT/HLA Database using the sequence submission tool provided (Robinson et al., 2020). The IPD-IMGT/ HLA Database may be accessed via the World Wide Web at: www. ebi.ac.uk/ipd/imgt/hla.

中文翻译:

HLA 系统因素的命名法,2020 年 7 月、8 月和 9 月更新*

自 2020 年 4 月、5 月和 6 月命名法更新(Marsh,2020 年)以来,以下序列已提交给命名法委员会,并且按照商定的政策,已分配官方等位基因名称(Marsh 等人,2010 年)。所有序列的完整细节将在即将发布的报告中公布。下面列出了新分配的序列(表 1)和先前报告序列的确认(表 2)。给出了每个序列的登录号,这些可用于从 EMBL、GenBank 或 DDBJ 数据库中检索序列文件。尽管数据库已经分配了登录号并且大多数序列已经可用,但仍有可能作者尚未允许发布该序列;在这种情况下,您必须直接联系提交作者。有关新序列的附加信息通常包含在描述这些等位基因的出版物中;表 3 列出了描述新 HLA 序列的最新出版物。此外,B*27:215N、DQA1*02:06 和 DPA1*02:02:02:06Q 的序列显示有错误,并且分别与 B*27:05:02:01、DQA1*02:01:01:01 和 DPA1*02:02:02:01 相同。现在已放弃名称 B*27:215N、DQA1*02:06 和 DPA1*02:02:02:06Q。此外,等位基因 C*12:274:02N、MICA*008:07 和 E*01:21:02N 被错误命名,现已更名为 C*12:329N、MICA*008:01:10 和 E* 01:117N,分别。现在,所有新的和验证性序列都应使用提供的序列提交工具通过 IPD-IMGT/HLA 数据库直接提交给世界卫生组织 HLA 系统因素命名委员会(Robinson 等,2020)。IPD-IMGT/HLA 数据库可通过万维网访问:www. ebi.ac.uk/ipd/imgt/hla。
更新日期:2020-10-30
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