Background and Objective: Emerging studies on the predictive value of Small Nucleolar RNA Host Gene 7 (SNHG7) in human neoplasms give evidence of the association of SNHG7 with the human tumor. However, whether SNHG7 can be utilized as a biomarker for carcinoma is still unknown. Therefore, this meta-analysis is aimed to assess the possibility of SNHG7 serving as a tumor biomarker.

Materials and Methods: 11 studies involving 814 cancer patients were retrieved from several databases, including PubMed, Embase, the Cochrane Library, and Web of Science from 1950 to Dec 27, 2019. Data on patient survival and several clinicopathological features were extracted and analyzed.

Results: Evident association between SNHG7 expression and poor Overall Survival (OS) was demonstrated (HR=1.84, 95% CI: 1.42-2.37) and high SNHG7 level was markedly correlated with tumor size (OR=2.01, 95% CI: 1.27-3.19), advanced clinical grade (III/IV) (OR=3.90, 95% CI: 2.63-5.80), Lymphatic Metastasis (LM) (OR=4.53, 95% CI: 2.71-7.55), and Distant Metastasis (DM) (OR=3.52, 95% CI: 2.58-4.80), except age and gender. Subgroup analysis showed that the predictive value of SNHG7 was consistent regardless of follow-up months, tumor location and sample size. Additionally, data from the R2 database also confirmed this association (p < 0.05). Publication bias was evaluated using Begg’s and Egger’s test.

Conclusion: SNHG7 could serve for a promising biomarker to predict prognosis, progression and metastasis of human solid cancer.

背景和目的：关于小核仁 RNA 宿主基因 7 (SNHG7) 在人类肿瘤中的预测价值的新兴研究提供了 SNHG7 与人类肿瘤关联的证据。然而，SNHG7是否可以用作癌症的生物标志物仍然未知。因此，本荟萃分析旨在评估 SNHG7 作为肿瘤生物标志物的可能性。

材料和方法：从 1950 年至 2019 年 12 月 27 日期间，从包括 PubMed、Embase、Cochrane 图书馆和科学网在内的多个数据库中检索了 11 项研究，涉及 814 名癌症患者。提取和分析了有关患者存活率和几个临床病理特征的数据。

结果：证明了 SNHG7 表达与总体生存率 (OS) 差之间的明显关联（HR=1.84，95% CI：1.42-2.37）并且高 SNHG7 水平与肿瘤大小显着相关（OR=2.01，95% CI：1.27- 3.19)、晚期临床分级 (III/IV) (OR=3.90, 95% CI: 2.63-5.80)、淋巴转移 (LM) (OR=4.53, 95% CI: 2.71-7.55) 和远处转移 (DM) （OR=3.52，95% CI：2.58-4.80），年龄和性别除外。亚组分析表明，无论随访月数、肿瘤位置和样本量如何，SNHG7 的预测值都是一致的。此外，来自 R2 数据库的数据也证实了这种关联（p < 0.05）。发表偏倚使用 Begg's 和 Egger's 检验进行评估。

结论：SNHG7可作为预测人类实体癌预后、进展和转移的有前景的生物标志物。