Background: The microbiome is now known for its important role in whole-body homeostasis. A dysbiosis of the normal microbiota is correlated with metabolic disorders. In this sense, the search for compounds able to modulate the microbiome is needed. Resveratrol, a natural compound found in grapes seems to be a promising candidate.

Objective: In this study, our motivation was to evaluate the effects of the association between Resveratrol and Lactococcus lactis, a probiotic, on the composition of the gastrointestinal microbiota and body weight of mice.

Methods: Twenty female mice were divided into 4 groups: (1) standard diet, (2) standard diet plus Lactococcus lactis, (3) standard diet plus resveratrol, and (4) standard diet plus Lactococcus lactis and resveratrol. At the end of the treatment period, samples of blood, mucus, stomach, and small and large intestines were collected for analysis. Total levels of Immunoglobulin A and Immunoglobulin E, Lac+ and Lac- bacteria and Lactobacillus were measured.

Results: The main results indicate that the association between resveratrol and probiotics was able to decrease mice body weight, as compared to the other groups, in addition to decrease the number of Lac- bacteria and increasing the number of Lac+ bacteria. The levels of secretory IgA were also decreased, compared to the animals treated with only probiotics or resveratrol.

Conclusion: We observed potential synergism between Resveratrol and Lactococcus lactis mainly in modulating the stomach and intestinal microbiota.

背景：微生物组现在以其在全身稳态中的重要作用而闻名。正常微生物群的失调与代谢紊乱有关。从这个意义上说，需要寻找能够调节微生物组的化合物。白藜芦醇是一种在葡萄中发现的天然化合物，似乎是一个很有前途的候选者。

目的：在本研究中，我们的动机是评估白藜芦醇和乳酸乳球菌（一种益生菌）之间的关联对小鼠胃肠道微生物群组成和体重的影响。

方法：20只雌性小鼠分为4组：（1）标准饮食，（2）标准饮食加乳酸乳球菌，（3）标准饮食加白藜芦醇，（4）标准饮食加乳酸乳球菌和白藜芦醇。在治疗期结束时，收集血液、粘液、胃和小肠和大肠的样本进行分析。测量了免疫球蛋白 A 和免疫球蛋白 E、Lac+ 和 Lac- 细菌和乳杆菌的总水平。

结果：主要结果表明，与其他组相比，白藜芦醇和益生菌之间的关联能够降低小鼠体重，此外还可以减少 Lac- 细菌的数量和增加 Lac+ 细菌的数量。与仅用益生菌或白藜芦醇治疗的动物相比，分泌型 IgA 的水平也有所降低。

结论：我们观察到白藜芦醇和乳酸乳球菌之间的潜在协同作用，主要是在调节胃和肠道微生物群方面。