Background: γ-Poly-Glutamic Acid (γ-PGA) is a naturally occurring homo-polyamide produced by various strains of Bacillus. It is made from repeating units of L-glutamic acid, D-glutamic acid, or both connected through amide linkages between α-amino and γ-carboxylic acid groups. As a biopolymer substance, the attractive properties of γ-PGA are that it is water-soluble, biodegradable, biocompatible, non-toxic, non-immunogenic, and edible. Therefore, it can be used as a green and environmentally friendly biological material.

Methods: The review concentrates on the reports revealing the functions and potential use of γ-PGA and its derivatives in medicine.

Results & Discussion: γ-PGA is described to possess several properties that may be exploited in medicine. The biopolymer reportedly has been successfully applied not only as a metal chelator, drug carrier/ deliverer, and gene vector, but also used safely as a vaccine adjuvant, tissue engineering material, and contrast agent.

Conclusion: γ-PGA could be potentially considered as a potential biomedical material in the field of medicine.

背景：γ-聚谷氨酸 (γ-PGA) 是一种天然存在的均聚酰胺，由各种芽孢杆菌菌株产生。它由 L-谷氨酸、D-谷氨酸或两者的重复单元通过 α-氨基和 γ-羧酸基团之间的酰胺键连接而成。作为一种生物高分子物质，γ-PGA 的吸引人的特性是它是水溶性的、可生物降解的、生物相容的、无毒、无免疫原性和可食用的。因此，它可以作为一种绿色环保的生物材料。

方法：审查集中在揭示γ-PGA 及其衍生物在医学中的功能和潜在用途的报告上。

结果与讨论： γ-PGA 被描述为具有多种可用于医学的特性。据报道，该生物聚合物不仅已成功用作金属螯合剂、药物载体/递送剂和基因载体，而且还可安全用作疫苗佐剂、组织工程材料和造影剂。

结论：γ-PGA 有潜力被认为是医学领域潜在的生物医学材料。