Flavonoids are plant products abundant in every day diets and are claimed to be beneficial for the human health. After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through the formation of flavonoids-SA complex. This review deals with the current state of knowledge on the flavonoids-SA complex forthe past 10 years, mainly involving multi-spectroscopic techniques and molecular dynamics simulation studies to explore the binding mechanism, thermodynamics and structural aspects of flavonoids, binding to SA. Especially, the novel methods such as capillary electrophoresis, high performance affinity chromatography approach, native mass spectrometry, and microscale thermophoresis, used in the characterization of the interaction between flavonoids and SA as well as flavonoid-based fluorescent probe for the SA measurement, are also included in this review.

类黄酮是每天饮食中含量丰富的植物产品，据称对人体健康有益。吸收后，类黄酮由血清白蛋白（SA）（最丰富的载体血液蛋白）转运，形成类黄酮-SA复合物。本文综述了过去10年中关于类黄酮-SA复合物的知识，主要涉及多光谱技术和分子动力学模拟研究，以探索类黄酮与SA的结合机理，热力学和结构方面。特别是毛细管电泳，高效亲和色谱法，天然质谱和微型热电泳等新方法，