Background: Rheumatoid Arthritis (RA) is a common connective tissue disease, characteristic of chronic and invasive synovitis in single or multiple joints and vasculitis. RA is a heterogeneous disease with unclear pathogenesis. Therefore, exploring the etiology and pathogenesis of the disease is essential for identifying new promising treatment strategies for RA. Accumulated data have implicated the significant role of non-coding RNA in RA, some of which are demonstrated to regulate inflammation and autoimmunity in RA through the Toll-Like Receptor (TLR) signaling pathway. To clarify the mechanism of non-coding RNA regulating the generation of proinflammatory mediators is helpful for understanding the pathogenesis of RA. Moreover, these well established non-coding RNAs can serve as novel biotargets for RA diagnosis and treatment.

Conclusion: Here, we summarize currently available data on non-coding RNAs, TLRs, and the underlying molecular mechanisms in RA. This review will provide insight into the potential use of noncoding RNA as disease diagnosis and treatment markers for RA.

背景：类风湿性关节炎（RA）是一种常见的结缔组织疾病，以单关节或多关节慢性侵袭性滑膜炎和血管炎为特征。RA是一种异质性疾病，发病机制不明。因此，探索该疾病的病因和发病机制对于确定新的有希望的 RA 治疗策略至关重要。积累的数据表明非编码 RNA 在 RA 中的重要作用，其中一些被证明通过 Toll 样受体 (TLR) 信号通路调节 RA 的炎症和自身免疫。阐明非编码RNA调控促炎介质产生的机制有助于理解RA的发病机制。此外，这些成熟的非编码 RNA 可以作为 RA 诊断和治疗的新型生物靶标。

结论：在此，我们总结了当前关于非编码 RNA、TLR 和 RA 潜在分子机制的可用数据。本综述将深入了解非编码 RNA 作为 RA 疾病诊断和治疗标志物的潜在用途。