Abstract

Glutamatergic transmission is responsible for most of excitatory synaptic processes in the central nervous system of vertebrates. Glutamatergic synapses are involved in the vast majority of physiological and pathological processes, and their modulation has a direct impact on almost all brain functions. It is not surprising that the development and research of drugs that can affect the glutamatergic synapses has been and remains one of the priorities of neuropharmacology. Even a brief overview of this complex problem cannot fit into a single article, so the review focuses on only one of the topics, namely, the ligands which directly block the ion pores of glutamate-activated channels.

中文翻译：

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离子型谷氨酸受体的通道阻滞剂

摘要

谷氨酸能传递是脊椎动物中枢神经系统中大多数兴奋性突触过程的原因。谷氨酸能突触参与绝大多数生理和病理过程，其调节对几乎所有脑功能都有直接影响。可以影响谷氨酸能突触的药物的开发和研究已经并且仍然是神经药理学的优先领域之一，这并不奇怪。即使是对这个复杂问题的简短概述也无法放在一篇文章中，因此，本文仅关注一个主题，即直接阻断谷氨酸激活通道离子孔的配体。