当前位置: X-MOL 学术J. Int. Neuropsychol. Soc. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Exercise, Arterial Stiffness, and Cerebral Vascular Function: Potential Impact on Brain Health
Journal of the International Neuropsychological Society ( IF 2.6 ) Pub Date : 2021-05-06 , DOI: 10.1017/s1355617721000394
Jill N Barnes 1, 2 , Andrew G Pearson 1 , Adam T Corkery 1 , Nicole A Eisenmann 1 , Kathleen B Miller 1
Affiliation  

Exercise is associated with higher cognitive function and is a promising intervention to reduce the risk of dementia. With advancing age, there are changes in the vasculature that have important clinical implications for brain health and cognition. Primary aging and vascular risk factors are associated with increases in arterial stiffness and pulse pressure, and reductions in peripheral vascular function.Objective:The purpose is to discuss the epidemiological, observational, and mechanistic evidence regarding the link between age-related changes in vascular health and brain health.Methods:We performed a literature review and integrated with our published data.Results:Epidemiological evidence suggests a link between age-related increases in arterial stiffness and lower cognitive function, which may be mediated by cerebral vascular function, including cerebral vasoreactivity and cerebral pulsatility. Age-associated impairments in central arterial stiffness and peripheral vascular function have been attenuated or reversed through lifestyle behaviors such as exercise. Greater volumes of habitual exercise and higher cardiorespiratory fitness are associated with beneficial effects on both peripheral vascular health and cognition. Yet, the extent to which exercise directly influences cerebral vascular function and brain health, as well as the associated mechanisms remains unclear.Conclusion:Although there is evidence that exercise positively impacts cerebral vascular function, more research is necessary in humans to optimize experimental protocols and address methodological limitations and physiological considerations. Understanding the impact of exercise on cerebral vascular function is important for understanding the association between exercise and brain health and may inform future intervention studies that seek to improve cognition.

中文翻译:

运动、动脉僵硬和脑血管功能:对大脑健康的潜在影响

运动与更高的认知功能相关,是降低痴呆风险的有希望的干预措施。随着年龄的增长,脉管系统发生了变化,这些变化对大脑健康和认知具有重要的临床意义。主要的衰老和血管危险因素与动脉僵硬度和脉压的增加以及外周血管功能的降低有关。客观的:目的是讨论关于血管健康与大脑健康的年龄相关变化之间联系的流行病学、观察和机械证据。方法:我们进行了文献回顾并与我们发布的数据相结合。结果:流行病学证据表明,与年龄相关的动脉僵硬度增加与认知功能降低之间存在联系,这可能由脑血管功能介导,包括脑血管反应性和脑搏动。与年龄相关的中心动脉僵硬度和外周血管功能损伤已通过运动等生活方式行为减轻或逆转。更多的习惯性运动和更高的心肺健康与对外周血管健康和认知的有益影响有关。然而,运动对脑血管功能和大脑健康的直接影响程度以及相关机制仍不清楚。结论:尽管有证据表明运动对脑血管功能有积极影响,但仍需要对人类进行更多研究以优化实验方案并解决方法学限制和生理考虑。了解运动对脑血管功能的影响对于了解运动与大脑健康之间的关系非常重要,并可能为未来寻求改善认知的干预研究提供信息。
更新日期:2021-05-06
down
wechat
bug