Peripheral T-cell lymphoma is a rare disease and remains a diagnostic challenge in some cases. Abnormally diminished expression of the pan T-cell markers (i.e. CD3, CD5, CD7, CD2) in flow cytometric immunophenotyping is a hallmark of peripheral T-cell lymphomas. CD3 is often used as a marker for mature T-lymphocytes and loss of cell surface CD3 on T-cells is a typical feature of the angioimmunoblastic T-cell lymphoma (Serke et al., 2000).

中文翻译：

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有 Muromonab-CD3 治疗史的患者的外周 T 细胞淋巴瘤免疫表型：病例报告和诊断困境

外周 T 细胞淋巴瘤是一种罕见疾病，在某些情况下仍然是诊断挑战。流式细胞免疫表型分析中泛 T 细胞标志物（即 CD3、CD5、CD7、CD2）的异常减少是外周 T 细胞淋巴瘤的标志。CD3 通常用作成熟 T 淋巴细胞的标志物，T 细胞上细胞表面 CD3 的缺失是血管免疫母细胞 T 细胞淋巴瘤的典型特征（Serke 等，  2000）。