Relapse in psychiatric disorders is highly distressing that posed a huge burden to the patients, family, and society. It interrupts the process of recovery and may increase the risk of resistance to treatment. Relapse detection and taking preventive measures against its possible factors are crucial for a better prognosis. To assess lifetime relapse and its associated factors among people with schizophrenia spectrum disorders who are on follow-up at Comprehensive Specialized Hospitals in Amhara region, Ethiopia. An institution-based cross-sectional study was conducted from July 13-August 13, at Comprehensive Specialized Hospitals in Amhara region, Ethiopia, 2020. Data were collected from 415 randomly selected participants using an interviewer administered questionnaire. Relapse was determined using participants’ medical records and a semi-structured questionnaire. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 25. Logistic regression analysis was done to identify the explanatory variables of relapse. Variables with P-value < 0.05 were considered significantly associated with relapse. The magnitude of lifetime relapse was 57.4% (95% CI = 53–62%). Relapse was significantly associated with comorbidity of another mental illness (AOR = 1.84, 95% CI = 1.06, 3.18), non-adherence to medication (AOR = 2.23, 95% CI = 1.22, 4.07), shorter duration on treatment (AOR = 1.71, 95% CI = 1.05, 2.81), and experiencing stressful life events (AOR = 2.42, CI = 1.2, 4.66). In the current study, more than half of the participants had lifetime relapses. Comorbid mental illnesses, non-adherence, duration of treatment ≤ 5 years, and experiencing stressful life events were factors associated with relapse. This requires each stakeholder to give concern and work collaboratively on the respective factors that lead to relapse.

中文翻译：

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在埃塞俄比亚阿姆哈拉地区综合专科医院接受随访的精神分裂症谱系障碍患者的终生复发及其相关因素：一项横断面研究

精神疾病的复发是非常令人痛苦的，给患者、家庭和社会带来了巨大的负担。它会中断恢复过程，并可能增加对治疗产生抵抗力的风险。复发检测和针对其可能因素采取预防措施对于更好的预后至关重要。评估在埃塞俄比亚阿姆哈拉地区综合专科医院接受随访的精神分裂症谱系障碍患者的终生复发及其相关因素。2020 年 7 月 13 日至 8 月 13 日，在埃塞俄比亚阿姆哈拉地区的综合专科医院进行了一项基于机构的横断面研究。使用采访者管理的问卷从 415 名随机选择的参与者中收集数据。使用参与者的病历和半结构化问卷确定复发。使用社会科学统计软件包 (SPSS) 第 25 版分析数据。进行逻辑回归分析以确定复发的解释变量。P 值 < 0.05 的变量被认为与复发显着相关。终生复发率为 57.4%（95% CI = 53–62%）。复发与另一种精神疾病的合并症显着相关（AOR = 1.84，95% CI = 1.06，3.18），不坚持药物治疗（AOR = 2.23，95% CI = 1.22，4.07），治疗持续时间较短（AOR = 1.71, 95% CI = 1.05, 2.81)，并经历压力性生活事件 (AOR = 2.42, CI = 1.2, 4.66)。在当前的研究中，超过一半的参与者终生复发。合并精神疾病，不依从，治疗时间≤ 5 年和经历压力性生活事件是与复发相关的因素。这需要每个利益相关者对导致复发的各个因素给予关注和协作。