Unsymmetrical tetradentate Schiff base Fe(III) and Cu(II) complexes were prepared by the coordination of some unsymmetrical tetradentate Schiff base ligands with CuCl₂·2H₂O or FeCl₃·6H₂O. The obtained complexes were characterized by ESI-MS, IR, and UV-Vis. The spectroscopic data with typical signals are in agreement with the suggested molecular formulae of the complexes. Their cyclic voltammetric studies in acetonitrile solutions showed that the Cu(II)/Cu(I) and Fe(III)/Fe(II) reduction processes are at (−)1.882–(−) 1.782 V and at (−) 1.317–(−) 1.164 V, respectively. The in vitro cytotoxicity of obtained complexes was screened for KB and Hep-G2 human cancer cell lines. The results showed that almost unsymmetrical tetradentate Schiff base complexes have good cytotoxicity. The synthetic complexes bearing the unsymmetrical tetradentate Schiff base ligands with different substituted groups in the salicyl ring indicate different cytotoxicity. The obtained Fe(III) complexes are more cytotoxic than Cu(II) complexes and relative unsymmetric Schiff base ligands.

中文翻译：

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不对称四齿席夫碱铜（II）和铁（III）配合物的合成，表征和体外细胞毒性。

通过一些不对称的四齿席夫碱配体与CuCl ₂ ·2H ₂ O或FeCl ₃ ·6H ₂ O的配位，制得不对称的四齿席夫碱式Fe（III）和Cu（II）配合物。 ，IR和UV-Vis。具有典型信号的光谱数据与所建议的配合物分子式一致。他们在乙腈溶液中的循环伏安研究表明，Cu（II）/ Cu（I）和Fe（III）/ Fe（II）的还原过程分别为（-）1.882-（-）1.782 V和（-）1.317- （-）分别为1.164V。在体外对于KB和Hep-G2人癌细胞系，筛选了获得的复合物的细胞毒性。结果表明，几乎不对称的四齿席夫碱复合物具有良好的细胞毒性。在水杨基环中带有不对称四齿席夫碱配体的合成配合物具有不同的细胞毒性。获得的Fe（III）配合物比Cu（II）配合物和相对不对称的席夫碱配体更具细胞毒性。