Advances in tissue mimetics are paving the way for interrogating both the pathobiology of human disease and innovative therapeutic paradigms. In this issue of Cell Stem Cell, Manian et al. (2021) develop a novel iPSC-derived retinal pigment epithelium (RPE)-choriocapillaris (CC) complex that recapitulates key features of macular degenerations.

中文翻译：

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克服建模黄斑变性的翻译障碍

组织模拟物的研究为质疑人类疾病的病理生物学和创新的治疗范例铺平了道路。在本期的细胞干细胞中，Manian等。（2021）开发了一种新颖的iPSC衍生的视网膜色素上皮（RPE）-脉络膜毛细血管扩张（CC）复合物，该复合物概括了黄斑变性的关键特征。