In this issue of Cell Stem Cell, Funato et al. (2021) and Bressan et al. (2021) use stem cells as models to define functions of the histone H3.3 G34R mutation in childhood gliomas. Both studies find strong regional specificity to oncohistone activity and implicate specific elements of an aberrantly locked-in neural progenitor transcriptional circuitry.

中文翻译：

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干细胞模型有助于破解驱动儿童神经胶质瘤的区域性癌组蛋白密码

在本期Cell Stem Cell中，Funato 等人。(2021) 和 Bressan 等人。(2021) 使用干细胞作为模型来定义组蛋白 H3.3 G34R 突变在儿童胶质瘤中的功能。两项研究都发现了对肿瘤组蛋白活性的强烈区域特异性，并暗示了异常锁定的神经祖细胞转录电路的特定元素。