Background: It is still debatable whether dog ownership during early childhood is a risk factor for the development of allergic diseases. Objective: We investigated the association of dog ownership in early life with sensitization and asthma in childhood. Methods: Data from the Cohort for Childhood Origin of Asthma and Allergic diseases were used to investigate the association between dog ownership at any time from pregnancy to 1 year of age and sensitization to aeroallergens at 3 and 7 years old, bronchial hyperresponsiveness (BHR), and asthma at 7 years old. We analyzed the cytokine levels in cord blood (CB) and indoor environmental measurement concentrations in the mother’s residence obtained at 36 weeks of pregnancy. Results: Sensitization to dogs at age 3 and 7 did not differ between dog ownership and nonownership, but dog ownership during early life decreased the risk of sensitization to aeroallergens at age 7 (aOR = 0.44, 95% CI 0.21–0.90). Dog ownership significantly increased the risk of nonatopic BHR (aOR = 2.86; 95% CI 1.32–6.21). In addition, dog ownership was associated with asthma, especially nonatopic asthma at 7 years old (aOR = 2.73, 95% CI 1.02–7.32; aOR = 7.05, 95% CI 1.85–26.90, respectively). There were no significant differences in the concentrations of IL-13 or interferon-γ in CB or indoor environmental measurements according to dog ownership during pregnancy. Conclusion: Early-life dog exposure in this birth cohort has been shown to reduce atopy but increase the risk of nonatopic BHR and nonatopic asthma at 7 years old.
Int Arch Allergy Immunol

中文翻译：

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早年养狗会增加儿童患非特应性哮喘的风险

背景：幼儿时期养狗是否是过敏性疾病发展的危险因素仍存在争议。目的：我们调查了生命早期养狗与儿童过敏和哮喘之间的关系。方法：使用来自哮喘和过敏性疾病儿童起源队列的数据来研究从怀孕到 1 岁的任何时间养狗与 3 岁和 7 岁对空气过敏原敏感、支气管高反应性 (BHR)、和 7 岁时的哮喘。我们分析了在怀孕 36 周时获得的脐带血 (CB) 中的细胞因子水平和母亲住所的室内环境测量浓度。结果：在 3 岁和 7 岁时对狗的敏感度在养狗和不养狗之间没有差异，但早年养狗会降低 7 岁时对空气过敏原敏感的风险（aOR = 0.44，95% CI 0.21–0.90）。养狗显着增加了非特应性 BHR 的风险（aOR = 2.86；95% CI 1.32–6.21）。此外，养狗与哮喘有关，尤其是 7 岁时的非特应性哮喘（aOR = 2.73，95% CI 1.02–7.32；aOR = 7.05，95% CI 1.85–26.90，分别）。根据怀孕期间养狗情况，CB 或室内环境测量中 IL-13 或干扰素-γ 的浓度没有显着差异。结论：该出生队列中的早期狗暴露已被证明可以减少特应性，但会增加 7 岁时非特应性 BHR 和非特应性哮喘的风险。
Int Arch 过敏免疫