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A review of chemosensors and biosensors for monitoring biofilm dynamics
Sensors and Actuators Reports Pub Date : 2021-05-05 , DOI: 10.1016/j.snr.2021.100043
Samuel C. Saccomano , Megan P. Jewell , Kevin J. Cash

Biofilms form complex structures that are ubiquitous in natural environments and can cause chronic infections which are difficult to treat. While much is known about biofilms, many questions remain about how biofilms mature and respond to internal and external stimuli. To understand the phenomena that occur within the biofilm matrix, sensing techniques capable of quantitatively resolving spatial and temporal dynamics of key analytes in the biofilm are needed. Biofilm spatial and temporal heterogeneity provide unique hurdles in fully assessing these intricacies. This review provides a detailed overview of methods that have been used to sense a variety of relevant analytes in biofilms. Electrochemical, optical, and other analytical techniques each possess distinct strengths and weaknesses depending on the application showing that biofilm sensing does not have a “one-size fits all” solution. The analyte being measured, the environment it is analyzed in, and the information that is needed determine whether known approaches may be appropriate or novel methods need to be developed. This review aims to help readers understand these techniques so that they can be applied to future projects for better understanding of biofilm elements and evolving sensing approaches.



中文翻译:

用于监测生物膜动力学的化学传感器和生物传感器的综述

生物膜形成在自然环境中无处不在的复杂结构,会导致难以治疗的慢性感染。尽管对生物膜的了解很多,但关于生物膜如何成熟以及对内部和外部刺激的反应仍然存在许多问题。为了理解生物膜基质中发生的现象,需要能够定量解析生物膜中关键分析物的时空动态的传感技术。生物膜的空间和时间异质性为全面评估这些复杂性提供了独特的障碍。这篇综述提供了已用于感测生物膜中各种相关分析物的方法的详细概述。电化学,光学,根据应用的不同,其他分析技术各有优缺点,这表明生物膜传感没有“千篇一律”的解决方案。被测分析物,被分析的环境以及所需的信息决定了已知方法是否合适或是否需要开发新方法。这篇综述旨在帮助读者理解这些技术,以便将其应用于未来的项目中,以更好地理解生物膜元素和不断发展的传感方法。

更新日期:2021-05-23
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