Results in Chemistry Pub Date : 2021-05-06 , DOI: 10.1016/j.rechem.2021.100140 Faqiong Ou , Zhenmei Lin , Li Li , Yaoping Tang , Ziqian Zhang
We have developed a galactosyl amino-naphthalimide based graphene oxide nanocomposite FN@GO that uses a unique mechanism: Förster resonance energy-transfer (FRET) controlled by interaction between ligands and receptors. The fluorophore stacking to surface of graphene oxide leads to a fluorescence quenching due to FRET. The galactosyl moiety of dye is a glycoligand that selectively recognized by the specific glycoprotein receptors on the surface of liver cancer cells. Therefore, our nanocomposite can provide a concise method to selectively probe HepG2 in cellular environment.
中文翻译:
打开荧光传感器,用于基于石墨烯氧化物纳米复合材料的糖基受体识别的特异性检测
我们已经开发出一种基于半乳糖氨基氨基萘酰亚胺的氧化石墨烯纳米复合材料FN @ GO,它使用一种独特的机制:通过配体和受体之间的相互作用控制的福斯特共振能量转移(FRET)。荧光团堆叠到氧化石墨烯的表面会由于FRET而导致荧光猝灭。染料的半乳糖基部分是一个糖配体,可以被肝癌细胞表面的特定糖蛋白受体选择性地识别。因此,我们的纳米复合材料可以提供一种简洁的方法来在细胞环境中选择性探测HepG2。