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Association between interleukin-1 alpha rs1800587 polymorphism and rheumatoid arthritis: A meta-analysis
Science Progress ( IF 2.1 ) Pub Date : 2021-05-05 , DOI: 10.1177/00368504211013647
Huaguo Wang 1 , Yi Wang 2
Affiliation  

No consistent results have been reached on the relationship of interleukin-1 (IL-1) rs1800587 polymorphism with the susceptibility to rheumatoid arthritis (RA) so far. Therefore, the current meta-analysis was designed to thoroughly review relevant studies, in order to examine the relationship of IL-1A rs1800587 polymorphism with RA risk. Electronic databases were retrieved for literature regarding the relationship between IL-1A rs1800587 polymorphism and RA vulnerability according to the inclusion and exclusion criteria. Stata 12.0 software was adopted to examine the enrolled literature. Meanwhile, odds ratio (OR) and corresponding 95% confidence intervals (95% CI) were used to evaluate the association. A total of seven case-control researches (3267 patients and 2960 healthy controls) were eventually enrolled into the current meta-analysis. Our data indicated no correlation of IL-1A rs1800587 polymorphism with RA risk (TT vs CC: OR = 0.90, 95% CI = 0.73–1.11; TC vs CC: OR = 1.02, 95% CI = 0.78–1.34; Dominant model: OR = 1.04, 95% CI = 0.80–1.35; Recessive model: OR = 1.91, 95% CI = 0.74–1.12). Similarly, no association was found in subgroup analysis stratified by ethnicity. Our findings indicated no relationship between IL-1A rs1800587 polymorphism and RA vulnerability.



中文翻译:

IL-1 α rs1800587 多态性与类风湿性关节炎之间的关联:荟萃分析

白细胞介素-1(IL-1)rs1800587多态性与类风湿性关节炎(RA)易感性的关系迄今尚未达成一致结果。因此,本次荟萃分析旨在全面回顾相关研究,以探讨IL-1A rs1800587多态性与RA风险的关系。根据纳入和排除标准检索电子数据库中有关IL-1A rs1800587多态性与RA脆弱性之间关系的文献。采用Stata 12.0软件对入组文献进行审查。同时,使用比值比 (OR) 和相应的 95% 置信区间 (95% CI) 来评估关联性。共有七项病例对照研究(3267 名患者和 2960 名健康对照)最终纳入当前的荟萃分析。我们的数据表明IL-1A rs1800587多态性与RA风险没有相关性(TT vs CC:OR = 0.90,95% CI = 0.73–1.11;TC vs CC:OR = 1.02,95% CI = 0.78–1.34;显性模型: OR = 1.04,95% CI = 0.80–1.35;隐性模型:OR = 1.91,95% CI = 0.74–1.12)。同样,按种族分层的亚组分析也没有发现关联。我们的研究结果表明 IL-1A rs1800587 多态性与 RA 脆弱性之间没有关系。

更新日期:2021-05-06
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