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Rebalancing the Oral Microbiota as an Efficient Tool in Endocrine, Metabolic and Immune Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets ( IF 1.9 ) Pub Date : 2021-05-01 , DOI: 10.2174/1871530320666200729142504
Ciro Gargiulo Isacco 1 , Andrea Ballini 2 , Danila De Vito 3 , Kieu Cao Diem Nguyen 4 , Stefania Cantore 1 , Lucrezia Bottalico 5 , Lucio Quagliuolo 6 , Mariarosaria Boccellino 6 , Marina Di Domenico 6 , Luigi Santacroce 7 , Roberto Arrigoni 8 , Gianna Dipalma 1 , Francesco Inchingolo 1
Affiliation  

The current treatment and prevention procedures of oral disorders follow a very targeted approach considering mouth and its structures as a system that is completely independent, than the rest of the body. The main therapeutic approach is to keep the levels of oral bacteria and hygiene in an acceptable range compatible with oral-mouth health, completely separated from systemic microbial homeostasis (eubiosis vs dysbiosis). This can negatively impact the diagnosis of a more complex systemic disease and its progression. Dysbiosis occurs as a consequence of imbalance in oral and gut microbiota which leads to cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, and Alzheimer’s disease, as reported in current literature. Likewise, there is a need to highlight and develop a novel philosophical approach in the treatments for oral diseases that will necessarily involve nonconventional approaches.



中文翻译:

重新平衡口腔微生物群,将其作为内分泌,代谢和免疫疾病的有效工具

当前的口腔疾病的治疗和预防程序遵循非常有针对性的方法,将口腔及其结构视为与身体其余部分完全独立的系统。主要的治疗方法是将口腔细菌和卫生水平保持在与口腔健康相适应的可接受范围内,与全身微生物体内稳态完全隔离(优生与营养不良)。这可能会对更复杂的系统性疾病及其进展的诊断产生负面影响。如目前文献所报道,由于口腔和肠道微生物群失衡而导致营养不良,导致心血管疾病,糖尿病,类风湿性关节炎和阿尔茨海默氏病。同样地,

更新日期:2021-05-06
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