Aims: This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of Asteriscus graveolens.

Background: Asteriscus graveolens (Asteraceae) is a medicinal plant widely used by the Moroccan population to treat various diseases, including diabetes.

Objective: This work aimed to assess the capacity of flavonoids extracted from Asteriscus graveolens (FEE) to improve diabetes mellitus and dyslipidemia in normal and STZ-induced diabetic rats.

Methods: Flavonoids were extracted from A. graveolens using the Soxhlet apparatus and using different organic solvents. Normal and streptozotocin-induced diabetic rats were treated orally by the extract of A. graveolens at a dose of 10 mg/kg. The oral treatment during 15 days was used to evaluate the effect of the flavonoids extracted from A. graveolens on blood glucose level and lipid profile in normal and diabetic rats. The oral glucose tolerance test, as well as the analysis of the histopathological examination of the liver, was performed. The antioxidant activity of FEE was also assessed by the method of trapping of free radical 2,2-diphenyl-1 picrylhydrazyl (DPPH), in order to estimate the mechanisms of action involved by FEE to improve hyperglycemia and lipid profile in normal and diabetic rats.

Results: FEE reduced serum glucose concentrations in both normal and diabetic rats and exhibited lowering total cholesterol and triglycerides effects as well as improvement of the HDL-cholesterol serum level in the last group. In addition, a remarkable influence on glucose tolerance was also noticed after FEE treatment. Moreover, FEE was able to improve the histopathological status of the liver and was found to possess a potent antioxidant effect in vitro.

Conclusion: In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of FEE in rats and supports its traditional use for the management of diabetes.

目的：本研究旨在评估Asteriscus graveolens的抗糖尿病和降血脂作用。

背景：紫草（Asteracecusgravolens）（Asteraceae）是一种被摩洛哥人广泛用于治疗包括糖尿病在内的各种疾病的药用植物。

目的：这项工作旨在评估从香菇中提取的黄酮类化合物改善正常和STZ诱导的糖尿病大鼠的糖尿病和血脂异常的能力。

方法：使用Soxhlet仪器并使用不同的有机溶剂从砾果曲霉中提取黄酮。正常和链脲佐菌素诱导的糖尿病大鼠通过以10 mg / kg的剂量服用砾石曲霉提取物口服治疗。在15天的口服治疗中，用于评估从砾果曲霉提取的类黄酮对正常和糖尿病大鼠血糖水平和脂质分布的影响。进行了口服葡萄糖耐量试验以及肝脏组织病理学检查的分析。FEE的抗氧化活性也通过捕获自由基2,2-二苯基-1甲基肼基（DPPH）的方法进行了评估，以评估FEE改善正常和糖尿病大鼠高血糖和血脂状况的作用机制。 。

结果：FEE降低了正常和糖尿病大鼠的血清葡萄糖浓度，并降低了总胆固醇和甘油三酸酯的作用，并改善了最后一组的HDL-胆固醇血清水平。此外，在FEE治疗后还发现了对葡萄糖耐量的显着影响。此外，FEE能够改善肝脏的组织病理学状态，并在体外具有有效的抗氧化作用。

结论：总之，本研究证明了FEE在大鼠中的降血糖和降血脂作用，并支持其在糖尿病管理中的传统用途。