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Comments on the evolution of TRPV6
Annals of Anatomy ( IF 2.2 ) Pub Date : 2021-05-06 , DOI: 10.1016/j.aanat.2021.151753
Karin Wolske 1 , Amanda Wyatt 1 , Ulrich Wissenbach 1
Affiliation  

It is well known that not all biological findings derived from animals can be directly applied to humans. The TRPV6 protein may serve as an example which highlights these inter-species differences as an example of parallel evolutionary pathways. TRPV6 (and TRPV5) belong to a family of ion channels from the transient receptor potential group but are selectively permeable for Ca2+, in contrast to other members of the family. Sequences with recognizable similarity to TRPV6 can already be found in archaebacteria. These ancient sequences show clear similarity to the ion-conducting pore of TRPV6. Over the course of evolution, the duplication of the TRPV6 gene gave rise to TRPV5. Duplications of the complete genome as well as subsequent loss of genetic material have led to a variety of different TRPV5/6 combinations. In addition, there is an N-terminal extension of the protein in placental animals. This extension causes translation of TRPV6 to be initiated from an ACG codon. Inactivation of one TRPV6 allele can be correlated with alcohol-independent pancreatitis in humans while inactivation of both alleles leads to skeletal dysplasia of newborn babies. The latter effect is not observed in mice, implying that the effects due to perturbations in TRPV6 levels are much more pronounced in humans.



中文翻译:

点评TRPV6的进化

众所周知,并非所有源自动物的生物学发现都可以直接应用于人类。TRPV6 蛋白可以作为一个例子,突出这些种间差异作为平行进化途径的一个例子。TRPV6(和 TRPV5)属于瞬时受体电位组的离子通道家族,但对 Ca 2+具有选择性渗透性,与其他家庭成员形成鲜明对比。在古细菌中已经可以找到与 TRPV6 具有可识别相似性的序列。这些古老的序列与 TRPV6 的离子传导孔明显相似。在进化过程中,TRPV6 基因的复制产生了 TRPV5。完整基因组的复制以及随后的遗传物质丢失导致了各种不同的 TRPV5/6 组合。此外,在胎盘动物中存在蛋白质的 N 端延伸。这种扩展导致 TRPV6 的翻译从 ACG 密码子开始。一个 TRPV6 等位基因的失活可能与人类不依赖酒精的胰腺炎相关,而两个等位基因的失活会导致新生儿骨骼发育不良。在小鼠中未观察到后一种效应,

更新日期:2021-05-11
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