Background: Trypanosomiasis is a widespread zoonotic disease and the existing drugs are not enough to prevent and treat it.

Objective: This study aimed to build a quantitative structure-activity relationship model by the chemical structures of a class of thiazolidone/thiazolidamide based hybrids. The model was used to screen new antitrypanosomal agents and predict the properties of composite molecules.

中文翻译：

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一类以噻唑烷酮/噻唑类为基础的抗锥虫药物的IC50的QSAR研究

背景：锥虫病是一种广泛的人畜共患疾病，现有药物不足以预防和治疗它。

目的：本研究旨在通过一类以噻唑烷酮/噻唑烷酰胺为基础的杂种的化学结构建立定量构效关系模型。该模型用于筛选新的抗锥虫药物并预测复合分子的性质。