当前位置: X-MOL 学术Gut Pathog. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Role of interferon gamma in SARS-CoV-2-positive patients with parasitic infections
Gut Pathogens ( IF 4.2 ) Pub Date : 2021-05-04 , DOI: 10.1186/s13099-021-00427-3
Enas Fakhry Abdel-Hamed , Mohamed N. Ibrahim , Nahed E. Mostafa , Howayda S. F. Moawad , Nahla E. Elgammal , Ehab M. Darwiesh , Dina S. El-rafey , Nissreen E. ElBadawy , Emad Ali Al-Khoufi , Salwa I. Hindawi

By 27 June 2020, almost half a million people had died due to COVID-19 infections. The susceptibility and severity of infection vary significantly across nations. The contribution of chronic viral and parasitic infections to immune homeostasis remains a concern. By investigating the role of interferon (IFN)-γ, we conducted this study to understand the connection between the decrease in numbers and severity of COVID-19 cases within parasitic endemic regions. Our research included 375 patients referred to hospitals for diagnosis of COVID-19 infection. Patients were subjected to full investigations, in particular severe acute respiratory syndrome coronavirus-2 nucleic acid and Toxoplasma IgM and IgG antibody detection, stool examination, and quantitative IFN-γ measurement. The majority of the studied cases had chest manifestation either alone (54.7%) or in association with gastrointestinal (GIT) manifestations (19.7%), whereas 25.6% had GIT symptoms. We reported parasitic infections in 72.8% of mild COVID-19 cases and 20.7% of severe cases. Toxoplasma gondii, Cryptosporidium, Blastocyst, and Giardia were the most common parasitic infections among the COVID-19 cases studied. The remarkable adaptation of human immune response to COVID-19 infection by parasitic infections with high levels of IFN-γ was observed in moderate cases compared with low levels in extreme cases. The potential therapeutic efforts aimed at the role of parasitic infection in immune system modulation are needed if this hypothesis is confirmed.

中文翻译:

干扰素γ在SARS-CoV-2阳性寄生虫感染患者中的作用

到2020年6月27日,将近50万人死于COVID-19感染。各国的感染敏感性和严重性差异很大。慢性病毒和寄生虫感染对免疫稳态的影响仍然是一个令人关注的问题。通过研究干扰素(IFN)-γ的作用,我们进行了这项研究,以了解寄生虫流行区域内COVID-19病例数的减少与严重程度之间的联系。我们的研究包括375例转诊至医院以诊断COVID-19感染的患者。对患者进行了全面检查,尤其是严重急性呼吸系统综合症冠状病毒2核酸和弓形虫IgM和IgG抗体检测,粪便检查和IFN-γ定量检测。大多数研究病例都是单独出现胸部表现的(54。7%)或与胃肠道(GIT)表现有关(19.7%),而25.6%的人有GIT症状。我们报告了轻度COVID-19病例中72.8%的寄生虫感染和重度病例中20.7%的寄生虫感染。在研究的COVID-19病例中,弓形虫,隐孢子虫,胚泡和贾第虫是最常见的寄生虫感染。在中等情况下观察到了人免疫对高水平IFN-γ寄生虫感染对COVID-19感染的显着适应,而在极端情况下观察到了低水平。如果这一假设得到证实,则需要针对寄生虫感染在免疫系统调节中的作用的潜在治疗努力。严重病例的7%。在研究的COVID-19病例中,弓形虫,隐孢子虫,胚泡和贾第虫是最常见的寄生虫感染。在中等情况下观察到了人免疫对高水平IFN-γ寄生虫感染对COVID-19感染的显着适应,而在极端情况下观察到了低水平。如果这一假设得到证实,则需要针对寄生虫感染在免疫系统调节中的作用的潜在治疗努力。严重病例的7%。在研究的COVID-19病例中,弓形虫,隐孢子虫,胚泡和贾第虫是最常见的寄生虫感染。在中等情况下观察到了人免疫对高水平IFN-γ寄生虫感染对COVID-19感染的显着适应,而在极端情况下则低。如果这一假设得到证实,则需要针对寄生虫感染在免疫系统调节中的作用的潜在治疗努力。
更新日期:2021-05-05
down
wechat
bug