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Evaluation of two calibration methods for MRI-based polymer gel dosimetry
Applied Radiation and Isotopes ( IF 1.6 ) Pub Date : 2021-05-05 , DOI: 10.1016/j.apradiso.2021.109754
Gopishankar Natanasabapathi 1 , Leighton Warmington 2 , Yoichi Watanabe 2
Affiliation  

Polymer gel dosimetry (PGD) can provide three-dimensional (3D) dose data for evaluation of the dose calculation algorithms used by treatment planning systems (TPS). Although the PGD technique, particularly with MRI, is now ready for clinical applications, an accurate calibration method is vital for treatment validation in 3D. This study evaluated the single-phantom electron beam (SPE) method that used the depth-dose data of a 9 MeV electron beam. This technique was compared with the multi-vial x-ray (MVX) method that used nine small vials irradiated with various doses. We tested two regression equations, i.e., third-order polynomial and tangent functions, and two dose-normalization methods, i.e., one-point and two-point methods. These methods were evaluated using a dose distribution generated by a 3 cm × 3 cm open arc beam. We used MAGAT polymer gel manufactured in-house. We found that the SPE method required a smaller dose scaling for the dose comparison. The tangent function showed better data fitting than the polynomial function with smaller uncertainty of the estimated coefficients. We did not observe a distinct advantage of the SPE method over the MVX method for the 3D dose comparison with the test case. From this study, we infer that the SPE method with the tangent function as the regression equation and one-point dose normalization is a good calibration option for the MRI-based polymer gel dosimetry.



中文翻译:

基于 MRI 的聚合物凝胶剂量测定的两种校准方法的评估

聚合物凝胶剂量学 (PGD) 可以提供三维 (3D) 剂量数据,用于评估治疗计划系统 (TPS) 使用的剂量计算算法。虽然 PGD 技术,尤其是 MRI,现在已准备好用于临床应用,但准确的校准方法对于 3D 治疗验证至关重要。本研究评估了使用 9 MeV 电子束的深度剂量数据的单幻影电子束 (SPE) 方法。该技术与使用九个不同剂量照射的小瓶的多瓶 X 射线 (MVX) 方法进行了比较。我们测试了两个回归方程,即三阶多项式和正切函数,以及两种剂量归一化方法,即单点法和两点法。使用由 3 cm × 3 cm 开弧光束产生的剂量分布评估这些方法。我们使用内部制造的 MAGAT 聚合物凝胶。我们发现 SPE 方法需要更小的剂量比例来进行剂量比较。正切函数显示出比多项式函数更好的数据拟合,估计系数的不确定性更小。在与测试案例进行 3D 剂量比较时,我们没有观察到 SPE 方法优于 MVX 方法的明显优势。从这项研究中,我们推断,以正切函数作为回归方程和单点剂量归一化的 SPE 方法是基于 MRI 的聚合物凝胶剂量测定的良好校准选择。在与测试案例进行 3D 剂量比较时,我们没有观察到 SPE 方法优于 MVX 方法的明显优势。从这项研究中,我们推断,以正切函数作为回归方程和单点剂量归一化的 SPE 方法是基于 MRI 的聚合物凝胶剂量测定的良好校准选择。在与测试案例进行 3D 剂量比较时,我们没有观察到 SPE 方法优于 MVX 方法的明显优势。从这项研究中,我们推断,以正切函数作为回归方程和单点剂量归一化的 SPE 方法是基于 MRI 的聚合物凝胶剂量测定的良好校准选择。

更新日期:2021-05-22
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