In this study, the rGO-PEI-AgNPs sensor was designed as a new effective platform to sensitive monitoring of deltamethrin in human plasma samples. For this purpose, reduced graphene oxide (rGO)-supported polyethylenimine (PEI) was used as a suitable substrate for dispersion of silver nanoparticles (AgNPs) as amplification and catalytic element. Therefore, a novel interface (rGO-PEI-AgNPs) was prepared by the fully electrochemical method on the surface of glassy carbon electrodes. The engineered nano-sensor showed a wide dynamic range of 10 nM to 1 mM and low limit of quantification (LLOQ) as 10 nM in human plasma sample, which revealed excellent analytical performance for the recognition of deltamethrin with high sensitivity and reproducibility through differential pulse voltammetry and square wave voltammetry techniques. The results confirm that rGO-PEI-AgNPs as a novel biocompatible interface can provide appropriate, reliable, affordable, rapid, and user-friendly diagnostic tools in the detection of deltamethrin in human real samples.

中文翻译：

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利用 rGO-PEI 支持的 AgNPs 灵敏识别人血浆样品中的溴氰菊酯：人体生物体液中农药生物医学分析的新平台

在这项研究中，rGO-PEI-AgNPs 传感器被设计为一种新的有效平台，用于灵敏监测人血浆样品中的溴氰菊酯。为此，还原氧化石墨烯（rGO）负载的聚乙烯亚胺（PEI）被用作分散银纳米颗粒（AgNPs）作为放大和催化元素的合适基材。因此，通过全电化学方法在玻碳电极表面制备了一种新型界面（rGO-PEI-AgNPs）。工程纳米传感器在人血浆样品中显示出 10 nM 至 1 mM 的宽动态范围和 10 nM 的低定量限 (LLOQ)，这表明通过差分脉冲识别溴氰菊酯具有高灵敏度和可重复性的出色分析性能伏安法和方波伏安法技术。