Non-alcoholic fatty liver disease (NAFLD) is a public health problem worldwide. This narrative Review provides an overview of the current literature to support the notion that NAFLD is a multisystem disease. Convincing evidence shows a strong association between NAFLD and the risk of developing multiple extrahepatic complications such as type 2 diabetes, cardiovascular disease (ie, the predominant cause of mortality in people with NAFLD), chronic kidney disease, and some types of extrahepatic malignancies. The magnitude of this risk parallels the severity of NAFLD (especially the stage of liver fibrosis). There are probably multiple underlying mechanisms by which NAFLD might increase the risk of cardiovascular disease, type 2 diabetes, and extrahepatic complications. Addressing the growing burden of NAFLD will require setting up a multidisciplinary working group and framework to progress and embrace novel collaborative ways of working to deliver holistic, person-centred care and management of people with NAFLD.

非酒精性脂肪性肝病 (NAFLD) 是世界范围内的公共卫生问题。这篇叙述性综述提供了当前文献的概述，以支持 NAFLD 是一种多系统疾病的观点。令人信服的证据表明，NAFLD 与多种肝外并发症的发生风险密切相关，例如 2 型糖尿病、心血管疾病（即 NAFLD 患者的主要死亡原因）、慢性肾病和某些类型的肝外恶性肿瘤。这种风险的程度与 NAFLD 的严重程度（尤其是肝纤维化阶段）相似。NAFLD 可能通过多种潜在机制增加心血管疾病、2 型糖尿病和肝外并发症的风险。