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Novel Synthesis of Maltol Capped Copper Nanoparticles and Their Synergistic Antibacterial Activity with Antibiotics
Plasmonics ( IF 3 ) Pub Date : 2021-05-05 , DOI: 10.1007/s11468-021-01452-3
Syeda Sumra Naqvi , Humera Anwer , Asma Siddiqui , Rashida Rehmat Zohra , Syed Abid Ali , Muhammed Raza Shah , Sobia Hashim

This study is the first-ever reported synthesis of maltol capped copper nanoparticles (McCuNPs) using maltol as a capping agent by chemical reduction scheme. Suitable surface plasmon resonance (SPR) band was achieved by optimizing parameters such as variable concentrations of copper sulfate, maltol, and sodium borohydride. McCuNPs were characterized by visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), and dynamic light scattering (DLS) techniques. Results revealed that the black-colored McCuNPs exhibited surface plasmon resonance band at 576 nm, and –OH, C–O, and C = O functional groups took part in the reduction of Cu+2 to Cu0. Synthesized McCuNPs were found to be monodispersed and spherical in shaped, with an average size of 50 nm (size range of 50–60 nm). Moreover, McCuNPs remained stable at 4 °C in an aqueous phase for 1 week in a tightly capped vial. The antimicrobial activity of McCuNPs (alone) and in combination with ciprofloxacin⋅HCl (Cip⋅HCl) and streptomycin sulfate (STR⋅SO4) was also investigated against clinical isolates of pathogenic bacterial strains by disc diffusion method. The McCuNPs alone showed zone of inhibitions against all tested strains, whereas its combination with Cip⋅HCl and STR⋅SO4 showed enhanced synergistic effect. However, Cip⋅HCl adsorbed McCuNPs revealed improved inhibition as compared to STR⋅SO4 adsorbed McCuNPs due to its active mode of action against these bacteria.

Graphical abstract



中文翻译:

麦芽酚包覆的铜纳米粒子的新型合成及其与抗生素的协同抗菌活性

这项研究是首次报道使用麦芽酚作为封端剂通过化学还原方案合成麦芽酚封端的铜纳米颗粒(McCuNPs)。通过优化参数,例如可变浓度的硫酸铜,麦芽酚和硼氢化钠,可以获得合适的表面等离振子共振(SPR)带。McCuNPs通过可见光谱,傅立叶变换红外(FTIR)光谱,原子力显微镜(AFM)和动态光散射(DLS)技术进行表征。结果表明,黑色的McCuNPs在576 nm处显示表面等离振子共振带,并且–OH,C–O和C = O官能团参与了Cu +2到Cu 0的还原。。发现合成的McCuNPs是单分散的,呈球形,平均大小为50 nm(大小范围为50-60 nm)。此外,McCoNPs在一个盖紧小瓶的水相中于4°C保持稳定1周。McCuNPs(单独)和在组合的同ciprofloxacin⋅HCl(Cip⋅HCl)和硫酸链霉素(STR⋅SO抗微生物活性4)也进行了调查针对纸片扩散法临床分离物的致病细菌菌株。单独的McCoNPs表现出对所有测试菌株的抑制区域,而其与Cip·HCl和STR·SO 4的组合则显示出增强的协同作用。然而,Cip⋅HCl吸附McCuNPs显示改进的抑制相比,STR⋅SO 4 由于其对这些细菌的主动作用方式,因此可以吸附McCoNPs。

图形概要

更新日期:2021-05-05
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