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Quinoxaline 1,4-di- N -oxides: a review of the importance of their structure in the development of drugs against infectious diseases and cancer
Medicinal Chemistry Research ( IF 2.6 ) Pub Date : 2021-05-05 , DOI: 10.1007/s00044-021-02731-8
Socorro Leyva-Ramos , Alberto Pedraza-Alvarez

Quinoxaline 1,4-di-N-oxides (QdNO’s) are potent drugs used since the middle of the last century as food additives to improve animal growth; however, their use as antibacterial agents led to an interest in investigating their mechanism of action, discovering that this heterocycle can cause DNA damage. Consequently, many molecules with different applications have been developed, with most of the research focused on studying their action as antibiotics, antifungals, antiparasitics, antituberculous, and anticancer agents. This review aims to present a condensate of the leading QdNO’s derivatives, as well as a description of the biological activities finding the importance of the nature and type of substituents present in positions R2, R3, R6, and R7 when they are biologically evaluated.



中文翻译:

喹喔啉1,4-二-N-氧化物:审查其结构在开发抗传染病和抗癌药物中的重要性

自上世纪中叶以来,喹喔啉1,4-二-N-氧化物(QdNO's)是有效的药物,可作为食品添加剂来改善动物的生长。然而,它们作为抗菌剂的使用引起了对研究其作用机理的兴趣,发现这种杂环会导致DNA损伤。因此,已经开发出许多具有不同应用的分子,其中大部分研究集中在研究其作为抗生素,抗真菌剂,抗寄生虫药,抗结核药和抗癌药的作用。这篇综述的目的是介绍主要QdNO's衍生物的缩合物,以及描述发现R 2,R 3,R 6位上存在的取代基的性质和类型的重要性的生物活性的描述。和R 7进行生物学评估时。

更新日期:2021-05-05
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