Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic ‘disinhibition’ phenotype. In a cohort of 117 individuals, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders.

冲动和强迫性问题行为与多种精神障碍有关。潜在表型表明冲动和强迫问题行为的表达主要受跨诊断“去抑制”表型的控制。在一组 117 人中，作为精神病学神经科学网络 (NSPN) 的一部分，我们研究了大脑功能连接组和网络特性与去抑制的关系。额叶（尤其是右侧额下回）、枕叶和顶叶区域的功能连接性降低与去抑制有关。研究结果提供了对冲动和强迫障碍出现背后的神经生物学途径的见解。