High-mobility group box-1 (HMGB1) and aberrant mitochondrial fission mediated by excessive activation of GTPase dynamin-related protein 1 (Drp1) have been found to be elevated in patients with pulmonary arterial hypertension (PAH) and critically implicated in PAH pathogenesis. However, it remains unknown whether Drp1-mediated mitochondrial fission and which downstream targets of mitochondrial fission mediate HMGB1-induced pulmonary arterial smooth muscle cells (PASMCs) proliferation and migration leading to vascular remodelling in PAH. This study aims to address these issues.

中文翻译：

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ERK/Drp1 依赖性线粒体裂变有助于 HMGB1 诱导的肺动脉高压自噬

已发现高迁移率族框 1 (HMGB1) 和由 GTPase 动力相关蛋白 1 (Drp1) 过度激活介导的异常线粒体裂变在肺动脉高压 (PAH) 患者中升高，并且与 PAH 发病机制密切相关。然而，Drp1 介导的线粒体裂变和线粒体裂变的下游靶点是否介导 HMGB1 诱导的肺动脉平滑肌细胞 (PASMCs) 增殖和迁移，导致 PAH 中的血管重塑，尚不清楚。本研究旨在解决这些问题。