Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which is also a dose-depedent toxin. APAP-induced acute liver injury has become one of the primary causes of liver failure which is an increasingly serious threat to human health. Neutrophils are the major immune cells in human serving as the first barrier against the invasion of pathogen. It has been reported that neutrophils patriciate in the occurrence and development of APAP-induced liver injury. However, evolving evidences suggest that neutrophils also contribute to tissue repair and actively orchestrate resolution of inflammation. Here, we addressed the complex roles in APAP-induced liver injury on the basis of brief introduction of neutrophil's activation, recruitment and migration.

中文翻译：

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中性粒细胞在 APAP 诱导的肝损伤中的复杂作用

对乙酰氨基酚（APAP）是一种广泛应用的缓解疼痛和发烧的药物，它也是一种剂量依赖的毒素。APAP引起的急性肝损伤已成为肝功能衰竭的主要原因之一，对人类健康的威胁日益严重。中性粒细胞是人体主要的免疫细胞，是抵御病原体入侵的第一道屏障。据报道，中性粒细胞参与 APAP 引起的肝损伤的发生和发展。然而，不断发展的证据表明，中性粒细胞也有助于组织修复并积极协调炎症的消退。在这里，我们在简要介绍中性粒细胞的激活、募集和迁移的基础上讨论了 APAP 诱导的肝损伤中的复杂作用。