Despite animal evidence of a role of calcium in the pathogenesis of spinal cord injury, several studies conducted in the past found calcium blockade ineffective. However, those studies involved oral or parenteral administration of Ca++ antagonists. We hypothesized that Ca++ blockade might be effective with local/immediate application (LIA) at the time of neural injury.

中文翻译：

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BAPTA，一种钙螯合剂，可在体外保护受损的神经元，并在体内促进脊髓横断后的运动恢复

尽管有动物证据表明钙在脊髓损伤发病机制中的作用，但过去进行的几项研究发现钙阻滞无效。然而，这些研究涉及 Ca++ 拮抗剂的口服或肠胃外给药。我们假设 Ca++ 阻滞剂在神经损伤时可能对局部/立即应用 (LIA) 有效。