Background. High-flow nasal cannula (HFNC) oxygen therapy has been recommended for use in coronavirus disease 2019 (COVID-19) patients with acute respiratory failure and many other clinical conditions. HFNC devices produced by different manufacturers may have varied performance. Whether there is a difference in these devices and the extent of the differences in performance remain unknown. Methods. Four HFNC devices (AIRVO 2, TNI softFlow 50, HUMID-BH, and OH-70C) and a ventilator with an HFNC module (bellavista 1000) were evaluated. The flow was set at 20, 25, 30, 35, 40, 45, 50, 60, 70, and 80 L/min, and the FiO₂ was set at 21%, 26%, 30%, 35%, 40%, 45%, 50%, 60%, 70%, 80%, and 90%. Then, one side of the cannulas was clipped to simulate the compression, bending, or blocking of the nasal cannulas. The flow and FiO₂ of the delivered gas were recorded and compared among settings and devices. Results. The actual-flow and actual-FiO₂ delivered by different settings and devices varied. AIRVO 2 had superior performance in flow and FiO₂ accuracy. bellavista 1000 and OH-70C had good performance in the accuracy of actual-flows and actual-FiO_2, respectively. bellavista 1000 and HUMID-BH had a larger flow range from 10 to 80 L/min, but only bellavista 1000 could provide a stable flow with an excessive resistance up to 60 L/min. TNI softFlow 50 had the best flow compensation and could provide sufficient flow with excessive resistance at 20–50 L/min. Conclusions. The variation in flow, FiO₂ settings, and devices could influence the actual-flow and actual-FiO₂ delivered. AIRVO 2 and OH-70C showed better FiO₂ accuracy. TNI softFlow 50, bellavista 1000, and HUMID-BH could lower the risk of insufficient flow support due to accidental compression or blocking of the cannulas. In addition, ventilators with HFNC modules provided comparable flow and FiO₂ and could be an alternative to standalone HFNC devices.

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不同高流量鼻插管设备中吸入氧气的流量和分数的实际性能比较：基准研究

背景。已建议将高流量鼻插管（HFNC）氧气疗法用于患有急性呼吸衰竭和许多其他临床状况的冠状病毒病2019（COVID-19）患者。不同制造商生产的HFNC设备可能具有不同的性能。这些设备是否存在差异以及性能差异的程度仍然未知。方法。评估了四个HFNC设备（AIRVO 2，TNI softFlow 50，HUMID-BH和OH-70C）和带有HFNC模块的呼吸机（bellavista 1000）。流量设置为20、25、30、35、40、45、50、60、70和80 L / min，FiO ₂设定为21％，26％，30％，35％，40％，45％，50％，60％，70％，80％和90％。然后，将插管的一侧剪裁以模拟鼻插管的压缩，弯曲或阻塞。记录输送气体的流量和FiO ₂，并在设置和设备之间进行比较。结果。不同设置和设备提供的实际流量和实际FiO ₂有所不同。AIRVO 2在流量和FiO ₂精度方面具有卓越的性能。bellavista 1000和OH-70C在实际流量和实际FiO ₂的准确性方面表现出色_，分别。bellavista 1000和HUMID-BH的流量范围较大，为10至80 L / min，但只有bellavista 1000才能提供稳定的流量，且阻力最高可达60 L / min。TNI softFlow 50具有最佳的流量补偿，并且可以在20–50 L / min的流量下提供足够的流量，但阻力过大。结论。流量，FiO ₂设置和设备的变化可能会影响实际流量和实际交付的FiO ₂。AIRVO 2和OH-70C显示出更好的FiO ₂精度。TNI softFlow 50，bellavista 1000和HUMID-BH可以降低由于意外压缩或插管阻塞而导致流量支持不足的风险。此外，配备HFNC模块的呼吸机可提供相当的流量和FiO ₂ 并可以替代独立的HFNC设备。