Produced by adipocytes, adiponectin crosses the blood-brain barrier to bind with specific receptors in the hypothalamus, brainstem, hippocampus, and cortex. In patients with major depressive disorder (MDD), circulating levels of adiponectin inversely related with antidepressant response to ketamine, and predicted a better response to multi-target drug combinations than to escitalopram. We investigated the effect of adiponectin on response to antidepressants in a naturalistic setting.

中文翻译：

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脂联素可预测重度抑郁症患者对抗抑郁药的不良反应

脂联素由脂肪细胞产生，穿过血脑屏障与下丘脑、脑干、海马和皮层中的特定受体结合。在重度抑郁症 (MDD) 患者中，脂联素的循环水平与对氯胺酮的抗抑郁反应呈负相关，并预测对多靶点药物组合的反应优于依他普仑。我们在自然环境中研究了脂联素对抗抑郁药反应的影响。